Treatment 1 Flashcards
What are the 2 broad families of treatment that are typically available?
Biomedical treatments: treatments aimed at directly altering the functioning of the brain (e.g., drugs, electric shocks, etc.)
Psychotherapy: treatments done through an interaction with a psychotherapist aiming to provide support and/or relief from the problem.
Which professions are responsible for administering the 2 different tratements?
Psychiatrist: a medical doctor (MD) who is allowed to prescribe medication but is often not trained in psychotherapy. (this is a specialization like pedeatrics for example.)
Clinical Psychologist: a psychologist with a doctorate degree who does research in clinical psychology and is trained in various forms of psychotherapy, but is not allowed to prescribe medication. (most psychologists take on an eclectic approach and apply a large variety of therapies dependent on the clients needs)
What are the 3 different aims/approached to treatment?
Direct intervention: address the “root of the problem” in hopes of eliminating the disorder. (Ex: if you think that automatic behaviours are the cause of a disorder we would focus on that, if we think that seratonin is the problem we will try to fix this)
Symptom support: alleviate the impairment of symptoms, but not the underlying cause. (there are many situations where we don’t think we can get to the root of the disorder. Will often teach coping or ways to minimize the impact. Most forms of psycho therapy are based on this.)
Insight: learn about likely causes of disorder to have patient decide how to deal with them. (belief that if a person gains understanding into why they are acting the way that they are acting, they may be able to fix the problem on their own.)
What are the 3 different aims/approached to treatment?
Direct intervention: address the “root of the problem” in hopes of eliminating the disorder. (Ex: if you think that automatic behaviours are the cause of a disorder we would focus on that, if we think that seratonin is the problem we will try to fix this)
Symptom support: alleviate the impairment of symptoms, but not the underlying cause. (there are many situations where we don’t think we can get to the root of the disorder. Will often teach coping or ways to minimize the impact. Most forms of psycho therapy are based on this.)
Insight: learn about likely causes of disorder to have patient decide how to deal with them. (belief that if a person gains understanding into why they are acting the way that they are acting, they may be able to fix the problem on their own.)
What are the problems with measuring the effectiveness of treatment?
- self report is unreliable.
- the relationship you form with your psychologist (theraputic alliance), may make you think that the treatment is helping, but it may actually be that the psychologist as a person is the thing that is helping.
- Patients tend to misremember how bad their symptoms were, and thus feel that the treatment must have worked.
- The worst symptoms often go on their own
- Symptoms naturally vary in severity, so some will go away on their own (“natural improvement”).
- Patients tend to seek treatment when they are at their worst, so they might improve even if they never got help. (This is a third variable problem. we don’t know the causal effect)
- Placebo effects
- Placebo: an inert substance or procedure that is applied with the expectation that
a healing response will be produced.
- a treatment has to work better than a placebo effect in order for us to know that it truly works.
What are the 2 key concepts you need to consider when evaluating treatment? Which one is always higher and why?
Efficacy: how well the treatment works in ideal conditions.
Effectiveness: how well the treatment works in real-life conditions.
Efficacy is always higher than effectiveness because: Treatment might be prohibitively expensive. Treatment might produce severe side-effects. Treatment might be stigmatized.
What is treatment outcome research/randomized Control Trial (RCT)? What is the procedure?
the “gold standard” type of experiment that assesses the efficacy and/or effectiveness of an intervention.
- Treatment group: assess initial symptoms, administer new treatments, assess symptoms again. We are testing the efficacy in this group.
- active control: assess initial symptoms, administer ‘standard’ or ‘mock’ treatment, assess symptoms again. A mock treatment is essentially a placebo treatment and it is only used when there is no standard.
- Inactive control: Assess initial symptoms, do nothing, assess symptoms again.
What is the point of the inactive control group? The active control?
inactive:
- Measures efficacy/effectiveness in comparison to doing nothing.
- Measures degree of natural improvement.
- Gives measure of patient bias for assessing pre- vs. post-symptoms.
- any difference seen in inactive control is natural improvement so we want to see more change than that
Active:
- Measures efficacy/effectiveness in comparison to doing something.
- Measures placebo effects
- if your treatment is better than the mock treatment you know that it is better than placebo, if you have something better than standard, then you know you have something better than the standard.
What is the biomedical approach?
treatments aimed at directly altering the functioning of the brain through drugs, stimulation, surgery, etc.
Type: biomedical.
Mechanism: direct intervention or symptom alleviation
Effectiveness: high; generally cheap and easy to administer with few side- effects.
Used for: most clinical disorders, but especially anxiety, depressive, bipolar, schizophrenia, and neurodevelopmental.
What are the 4 relevant neurotransmitters and what do they do?
Serotonin: primarily related to feelings of well-being, appetite, and sleep.
Dopamine: primarily related to increasing activity in various brain regions, especially those related to reward and pleasurable feelings.
GABA: primarily related to inhibiting neuronal activity (more GABA = less activity).
Norepinephrine: primarily related to increasing arousal and sense of altertness,
especially during the stress response.
What are antipsychotics? What are the 2 major types?
Antipsychotics: drugs primarily used to treat psychotic conditions.
Two major types:
- Conventional/Typical: exclusively block dopamine receptors, reducing the effects of dopamine in the brain. Especially good for helping treat positive symptoms, including auditory hallucinations. (this used to be the gold standard because they are really effective at treating symptoms of schizophrenia. Believed to reduce institutionalization of people with schizophrenia.)
- Atypical: block activity of both serotonin and dopamine. Results in fewer side- effects and help with some of the negative symptoms. (these result in fewer side effects and help more with a lot of the negative symptoms.)
What are antipsychotics used for? What is the effectiveness, limitations, and side effects?
Used For: schizophrenia, bipolar, treatment-resistant depression.
Effectiveness: the most effective treatment available for schizophrenia (especially positive symptoms), and have over the years cut the number of patients in psychiatric hospitals by two thirds.
Limitations: significant side-effects and not always as good for negative symptoms.
Side-Effects: weight-gain, involuntary muscle movements (dykinesia), diabetes, potential for some serious drug interactions. (it is the best available treatment but it is really difficult to treat overtime.)
What are anxiolytics/anti-anxiety? What are the three major types?
drugs used to treat anxiety; their popularity has
been decreasing due to tendency for abuse and adverse interactions.
Three major types:
- Benzodiazepines: drugs that increase GABA and decrease brain activity; most commonly administered and most effective anxiolytic. (leads to some dangerous longterm conditions)
- Buspirone / Wellbutrin: drug that stabilizes serotonin levels and is often used with comorbid depression.
- Beta Blockers: drugs that block norepinephrine and thus control muscle tension, blood pressure, and heart rate.
What are anxiolytics used for? effectiveness, limitations, side effects?
Used For: anxiety (general and specific), sleep disorders, PTSD, OCD.
Effectiveness: very high for most people, but not prescribed as often as they used to be.
Limitations: only alleviates symptoms, builds strong drug-tolerance, requiring higher and higher doses that can lead to addiction.
Side-Effects: withdrawal after tolerance, drowsiness, issues with motor coordination, potentially deadly when combined with alcohol (especially benzodiazepines).
What are antidepressants? What are the 2 major types?
Antidepressants: medication used to treat depression, anxiety, and several other disorders; the most commonly prescribed psychopharmacological medication in the world.
Two major types used today:
Selective Serotonin Reuptake Inhibitors (SSRIs): drugs that increase the amount of serotonin in the brain; historically the most popular anti-depressants.
Serotonin-Norepinehprine Reuptake Inhibitors (SNRIs): drugs that increase both serotonin and norepinephrine, and are increasing in popularity today due to lower side-effects than SSRIs.
What are antideperessants used for? effectiveness, limitations, side effects?
Used For: depression, anxiety, addiction, PTSD, OCD. Effectiveness: very high (when they are working)
Limitations: take time to start working (usually 1-3 months); require increasing dosage or change over time.
Side-Effects: very few for modern antidepressants – weight gain, reduced sexual desire, and rarely serotonin toxicity.
What are mood stabilalizers? What are the 2 major types?
Mood Stabilizers: drugs used to treat bipolar disorder that attempt to
decrease the severity of depressive and manic episodes.
Two major types:
Mineral Salts/Lithium: class of drugs that occur naturally and help decrease adrenaline and increase serotonin, thus helping with both mania and depression. Most commonly administered mood stabilizers.
Anticonvulsant: class of drugs that increase GABA and norepinepherine and especially help during manic episodes. They are also used to help prevent seizures in epileptic patients.
What are mood stabilizers used for? effectiveness, limitations, side-effects?
Used For: bipolar.
Effectiveness: very high in correct dose for many patients, but doesn’t work universally for everybody.
Limitations: big individual differences, thus requiring frequent visits to psychiatrist to adjust dose; required dose can also change over time.
Side-Effects: can cause kidney and thyroid damage if dose is wrong, drowsiness, muscle weakness.
What are psychostimulants?
Psychostimulants: drugs used to treat attentional disorders, including ADHD. Selectively release norepinephrine, serotonin, and dopamine in prefrontal cortex of the brain, boosting ability to pay attention.
Unlike other psychoactive drugs, psychostimulants are frequently abused, and overdoses can be fatal.
There is continued debate over whether psychostimulants should be allowed for people not suffering from attention problems to generally boost performance.
what are psychostimulants used for? Effectivness, limitations, side effects?
Used For: ADHD, depression, eating disorders.
Effectiveness: very high, though likely overprescribed.
Limitations: tolerance build-up; addictive, especially with recreational use.
Side-Effects: insomnia, irritability, weight-loss drowsiness, decreased inhibitory control in high doses.
how do biomedical approaches function?
by changing the functioning of the brain, either through neurotransmitters (drugs) or by more invasive measures (e.g., ECT – check out your textbook).
What is true about the variability, efficacy and effectiveness of biomedical approaches?
They are generally high in effectiveness and efficacy, but also show widespread individual differences and often do not treat the underlying problem.
How are most disorders treated today?
As we will learn on Wednesday and Friday, most clinical disorders today are therefore treated by a mixture of medication and psychotherapy.
what is psychotherapy? What are the 2 broad families?
Psychotherapy: treatments done through an interaction with a professional
psychotherapist. (the building of a therapeutic alliance)
Two broad “families”:
Insight-focused therapies: goal is primarily to give client insight into the cause of their disorder.
Intervention-focused therapies: goal is primarily to help client change their thinking and behaving to help them cope with symptoms and/or directly address the cause of the disorder.