Treating N/V Flashcards
1
Q
Drugs in Neurokinin (NK) -1 Receptor Antagonists
- MOA
A
- Aprepitant: Emend
- Fosapreptitant
- Should use in combo w/ other antiemetics: serotonin antagonist and corticosteroids
- MOA: block substance P, which is thought to activated a pathway in the brain that cause n/v
2
Q
Anzemet
- Route
- Dose:
A
DOLasetron
- IV and PO
- 100 mg single dose 30(IV) - 60(PO) min prior to chemo
3
Q
Kytril
Sancuso
- Route
- Dose:
- Patch: avoid
A
Granisetron
- IV/PO/Transdermal (Sancuso)
- Dose: 1mg IV or 1-2mg PO
- Patch: 1 patch Q24-48H b/4 chemo. Can be wore for up to 7 days. Avoid sun
4
Q
Zofran
- Route
- Dose:
A
Ondansetron
- IV/IM/PO/ODT (thin strip Zuplenz)/sol’n
- 8 mg can be repeated q8h
5
Q
Aloxi
- Rec to use if concern of:
- Route
- Half life
- Dose
A
PaLONosetron
- Use this if worry about QT prolongation
- IV/PO
- Longer half life 36-48H
- Dose: 0.25mg IV or 0.5mg PO 30 min prior to chemo
6
Q
Decadron(R)
- ppx dose:
- tx dose:
A
Dexamethazone
- PPX dose: 8mg IV or 12 mg PO prior to chemo;
8 mg PO QD for 2-4 days - Treatment dose: 10-20 mg IV/PO Q4-6H
7
Q
Medrol
A
Methylprednisolone
8
Q
Corticosteroids
- Drugs
- Common ADEs
A
- Dexamethaxone: Decadron
- Methylprednisolone: Medrol
- Use alone or w/ 5HT3 antagonists
SEs
- Upset stomach
- Anxiety
- Trouble sleeping
- Increased BG (hyperG) when used for several days
9
Q
Emend
IV
- Metabolize
- Level of emetogenic
- Dose:
PO
- Dose
- Use in combo with
- DDI
A
Fosaprepitant: IV
- Prodrug rapidly convert to aprepitant
- Highly emetogenic chemo
- Injection (On D1 = 115 mg IV given over 15-30 min
Aprepitant: PO
- 125 mg D1; then 80 mg D2 and D3
- Use in combo w/ dexamethasone and ondansetron
DDI
- Inducer
10
Q
Marinol
- Class
- Control Schedule
- Dosage Frequency
- Storage
- Indications
A
DRONabinol
- Class: cannabinoids
- Schedule III
- Take TID-QID
- Refrigerated
- Indication: stimulate appetite in AIDS pt, CINV
11
Q
Cesamet
- Class
- Control Schedule
- Dosage Frequency
- Storage
A
Nabilone
- Class: cannabinoids
- Schedule II
- BID
- Storage: RT
12
Q
Reglan
- Class
- MOA:
- ADEs:
- Special SEs
- Never give it to
A
Metoclopramide
- Class: Benzamides
- MOA: blocks dopamine in brain that contain the vomiting center.
- ADEs: diarrhea, drowsiness, anxiety, depression
- Extrapyramidal (spasms): Benadryl can help ease some ADEs
- Never give to parkinson’s disease
13
Q
Antihistamines
- Drugs
- ADEs
A
- Benadryl and hydroxyzine
ADEs
- Mild relaxation
- Drowsiness
- Dry mouth, constipation (anti-cholinergic)
14
Q
Benadryl
A
Diphenhydramine
15
Q
Atarax
A
Hydroxyzine
