Brands/Generics/Class Flashcards
Anzemet
- Forms
- Class
Dolasetron
- Form: IV & PO
- Class: 5-HT3 Serotonin Receptor Inhibitors
Kytril
Sancuso
- Form
- Sancuso
- Kytril
- Class
Granisetron
- Form IV/PO
- Sancuso: Transdermal 1 patch Q24-48H b/4 chemo. Can be worn for 7 days. Avoid sun
- Class: 5-HT3 Serotonin Receptor Inhibitors
Zofran
Zuplenz
- Form
- Class
Odansetron
- Zofran IV/IM/PO/ODT
- Zuplenz: thin strip melts on tongue
- Class: 5-HT3 Serotonin Receptor Inhibitors
Aloxi
- Form
- Half life
- Class
PaLONosetron
- IV/PO
- LONg t1/2. Use this if worry ~ QT
- Class: 5-HT3 Serotonin Receptor Inhibitors
Decadron
Dexamethasone
- Corticosteroids
Medrol
Methylprednisolone
- Corticosteroids
Emend
- Metabolize
- Class
- Use in combo:
Fosaprepitant (pro-drug): IV
Aprepitant PO
- Rapidly convert to aprepitant
- Class: Neurokinin-1-receptor antagonists => working by blocking substance P
- Used in combo with corticosteroid or 5HT3 inhibitors
Marinol
- Class
- Storage
- Frequency
- CS:
DRONabinol
- Class: Cannabinoids
- Refridgerated
- TID-QID
- CS: III
Cesamet
- Class
- Storage
- Frequency
- CS
NaBilone
- Class: Cannabinoids
- Non-refrigerated
- BID
- CS: II
Reglan
- Form
- MOA
- Give w/ what to reduce what SEs
Metoclopramide
- PO/IV/IM
- MOA: Block dopamine in brain
- Give w/ Benadryl to reduce extrapyramidal SEs
Diphenhydramine
- Benadryl
- Class: Antihistamines
Atarax
- Class
HyDROXyzine
- Class: Antihistamines
Lorazepam
- Class
Ativan
- Class: Benzodiazepines
Alprazolam
- Class
Xanax
- Class: Benzodiazepines
Epogen
Procrit
- Indication:
- Dose/Form/Frequency
- Exp of Multi-vial
Erythropoietin
- Indication: for chemo induced anemia
- 150-300 units/kg SC/IV 3x/wk
- Multi-dose vials: discard 21 days after initial entry
Aranesp
- Indication:
- Dose/Frequency
- Counseling on bottle
- Storage:
- – Epogen and Aranesp —-
- CI
- Warning
- Monitoring
DARbepoetin alfa
- Indication: for chemo induced anemia
- 2.25 mg/kg SC weekly
- Do not shake
- Refrigerate/protect from light
—— Epogen, Procrit, Aranesp—-
- CI: Uncontrolled HTN
- Warning: CVD, thromboembolic event, tumor progression.
D/C if Hgb b/w 10-12.
- Monitor:
BP, CBC w/ diff, Hgb
Ferritin: low (give iron, B12, and folate)
Neumega
- Indication:
- MOA:
- Dose/Route
- Monitor
Oprelvekin (Oh Prel ve kin)
- I: chemo induced thrombocytopenia
- MOA: Interleukin -11 (IL-11) is a thrombopoietic growth factor that increases platelet production
- Dose: 50 mcg/kg SQ QD start 6-24H after chemo & cont until platelets count is >50000 cells/mL
- Monitor: Fluid retention and electrolyte => CHF and arrhythmia
Neupogen
- Indication
- Storage
- Dose
- SEs
FilgrasTIM GCSF
- I: granulocytes to tx neutopenia. Use to reduce febrile neutropenia after chemo
- Refrigerate: use w/in 24H if at RT
- D: 5mcg/kg/day ingle dose SC or IV infusion over 15-30min
- SE: bone pain
Neulasta
- Indication:
- Storage
- Dose
- SEs
PegfilgrasTIM
- I: granulocytes to tx neutopenia. Use to reduce febrile neutropenia after chemo
- Refridgerate/protect from light. Use w/in 48H at RT
- Dose: 6mg SC x 1 each chemo cycle
- SE: bone pain
Kayexalate
Sodium polystyrene sulfonate (SPS)
- I: Shift K intracellular
Chemo drugs are never in mg/kg, it’s in:
- mg/m2
One inch = ? cm
1’ = 2.54 cm
1kg = ? lb
1 kg = 2.2 pounds
PLANTINol
- Class:
- SEs
- Cause most:
- Give w/ what as ppx to prevent nephrotoxic
- Give what for promote excretion
- Reduce nephrotoxicity by:
CisPlatin
- Alkylating agents
SEs
- Nephrotoxicity
- Ototoxicity
- Peripheral Neuropathy
- Electrolyte imbalance: decr PO4, K, Ca, Mg
- Cause MOST GI upset
- Amifostine: given as ppx to prevent nephrotoxicity
- Manitol: promote excretion
Reduce Nephrotoxicity by:
- Hydration: 2-3L NS over 8-12H
- Mannitol 25-50g IV b/4
- Amifostine: start b/4 chemo
Ethyol
- Indication
- SEs
- D/C which med:
Amifostine
- Give as ppx to prevent nephrotoxicity in cisplatin
SEs
- Severe HyperTN
- Infusion rxn: flushing, chills, hiccups, sneezing, n/v
- D/c all HTN med
Paraplatin
- Is amifostine indicated for this drug?
Carboplatin
- Amifostine is no indicated => cause less nephrotoxicity
Eloxatin
- Indication
- SE
OxaliPtin
- Use for colorectal cancer w/ 5-FU + leucovorin
- SE: Peripheral neuropathy
Myleran
- SEs
Busulfan
SEs
- Increase uric acid (Hyperuricemia):
Watch for other drugs (thiazide, loop, niacin, low dose ASA)
- Pulmonary fibrosis (SOB & chest x-ray)
- Hyperpigmentation of skin: stop ASAP and give steroid
- SZ
- BMS
Cytoxan
- Prevent hemorhagic cystitis
- SEs
- Monitor
C(4)yclophoSphamide
Prevent hemorhagic cystitis
- Mesna to bind to acrolein
- Hydration
SEs
- Hemorhagic cystitis: cause by acrolein
- Renal tubular necrosis
- Hepatotoxicity
- Cardiac SEs
- Alopecia
- Sterility
Monitor
- CBC, plt, BUN, UA, Electrolytes, SrCr
Ifex
- Mesna
Ifosfamide
- Mesna comes with the ifosfamide package
Mesna indication
- Bind to acrolein as ppx to prevent hemorhage cystitis in cyclophosphamide and ifosfamide
BiCNU
- Indication:
- SEs
C(2)ARMustine
- I: lipid soluble => treat cns malignancies (brain tumor)
SEs
- Hepatotoxicity
- Nephrotoxicity
- Pulmonary fibrosis => CAR = carbon dioxine = lung toxic
- Bone marrow suppression
CeeNu
- Indication:
- SEs
Lomustine
- I: lipid soluble => treat cns malignancies (brain tumor)
SEs
- Hepatotoxicity
- Nephrotoxicity
- Bone marrow suppression
- Pulmonary fibrosis
Zanocar
- SEs
- Dose limiting due to
StrEptozocin
SEs
- Pancreatic damage
- Nephrotoxicity
- Extravasation
- Dose limiting - 90% get DM I
Alkeran
- SEs
Melphalan
SEs
- Fertility Impairment
- BMS
Which drug cause fertility imp and no pharmacist can work while pregnant
- Melphalan (Alkeran)
- Mechlorethamine (Mustargen)
- Altretamine (Hexalen)
Mustargen
- SEs
mEchlorethamine
SEs
- Extravasation: severe necrosis => tx w/ Na thiosulfate
- Fertility impairment
Hexalen
- Route
- Indication
- SEs
- MOAIs:
Altretamine
- PO
- I: tx ovarian cancer
SEs
- Peripheral Neuropathy
- Fertility Impairment
- MOAIs: may cause severe othostatic hypoTN
Mutalane
- SEs in Pediatric
- Monitor:
- Give with MOAIs
Procarbazine
- SEs in Ped: tremors, convulsion
- Disulfiram rxn
- M: CBC, renal, hepatic
- MOAIs: high tyramines or MOAIs = fatal HTNsive crisis
Drugs that have MOAI effects
- Altretamine (Hexalen)
- Procarbazine (Mutalane)
Drugs Cause Tumor Lysis Syndrome
- Bendamustin (Trenda)
Anti-Metabolites
Anti-Metabolites
Folinic acid
- Indication
Leukovorin
- Give with methotrexate as a rescue drug to save the good cells
- Give with 5-FU to increase its action. When used together, 5-FU works better, thus use less amt of 5-FU
Glucarpidase (Voraxaze)
- Indication
- An injectable carboxypeptidase enzyme that breaks down MTX in the body so the drug can be easily eliminated when the kidneys are not working properly
5-FU
Adrucil
- INR
- SEs
FluOrouracil
- Increase INR
SEs
- Hand & foot syndrome
- Mucositis
- Neurotoxiticy
- Alopecia
- Ocular toxicity
- Photosensitivity
- Light sensitive
Light sensitive drugs
- Methotrexate
- 5-FU
- Cisplatin
Xeloda
- Indication
- Dose:
- Administration
Capecitabine - prodrug of 5-FU
Indication
- Metastatic breast cancer resistant to paclitaxel
- 1st line for metastatic colorectal carcinoma
- Dosage Form: PO 150 mg and 500 mg Tab
- D: Cyclical 1250 mg/m2 BID - 2 wk on 1 wk off
- Take with water w/in 30 min after AM and PM meals