Treating High Blood Pressure

Question 1

What are the mechanisms used to treat high blood pressure?

Answer 1

• reducing water absorption/increase water secretion (Diuretics)
• reducing sodium reabsorption

Question 2

Types of Diuretics

Answer 2

• V2 receptor antagonists (directly blocking ADH from binding to receptors)
• NKCC2 antagonists (blocks NKCC2 symporter - therefore it prevents ion reabsorption)

NCC antagonists - blocks NCC symporter - therefore it decreases sodium reabsorption)

ACE inhibitors - prevents angiotensin l to ll conversion - therefore, prevents Na reabsorption and promotes vasodilation)

Angiotensin ll receptor blockers - prevents binding of Angiotensin ll to receptor - therefore, decreases sodium reabsorption

Aldosterone receptor blockers - block aldosterone from binding to receptor - therefore, reduces sodium reabsorption and prevents K secretion

Sodium channel blockers - inhibits epithelial sodium channels - therefore, reduces sodium reabsorption and prevents K secretion