Transporters Flashcards
1
Q
Phenylephrine
A
- Acts at alpha 1 receptors on the post synaptic membrane to cause vasoconstriction
- removed and taken back up into the nerve where it can be metabolised
- Prasozin an alpha 1 receptor antagonist would prevent phenylephrine from working
2
Q
Cocaine
A
- Noradrenaline reuptake blocker
3
Q
Methamphetamine
A
- indirectly acting sympathomimetic
- Taken up into prejunctional nerve via the transporter and then cause the release of noradrenaline
4
Q
Treatment of anxiety disorders
A
- SSRI’s
- Monoamine oxidase inhibitors
- Tricyclic antidepressants
5
Q
Treatment of manic disorders
A
-Lithium, facilitates re-uptake of serotonin and noradrenaline
6
Q
Parkinsons disease
A
- Amantadine: Dopamine re-uptake inhibitor
7
Q
ADHD
A
Indirectly acting sympathomimetics (ritalin and adderal)
or
transport inhibitors: atomoxetine
8
Q
ALD and MND
A
Riluzole increases uptake of glutamate to slow excitotoxicity of neurones
9
Q
Neuropathy
A
Pregabalin upregulates the GABA transporter to treat neuropathic pain
10
Q
Atherosclerotic vascular disease
A
ezetemibe prevents uptake of cholesterol via inhibition of a transporter
