transport Flashcards
types
simple diffusion, pumps (ATP), channel (facilitative/passive), transporter (uniporter, cotransporter (symporter, antiporter))
facilitated transport speed
faster than simple diffusion but saturable (limited to the amount of unitransporter available, Km is the half maximal point)
GLUT1/2 type
facilitative
GLUT 1/2 forms
glucose binding site faces outside/inside of cell
aquaporin type
uniporter
aquaporin structure
tetramer, each subunit has 6 A-helices, does not undergo confirmational change
4 classes of ATP pumps
P-class pump, V-class proton pump, F-class proton pump, ABC superfamily
P-class pump
maintains ion gradients, has to be phosphorylated
V-class proton pump
couple ATP hydrolysis to transport protons against concen grad
F-class proton
pumps H+ in for ATP synthesis
ABC superfamily
some transport ions, mainly small molec and drugs