Transport 2 Flashcards
What are the three ways to deliver material to pathways?
Via Autophagy, Via phagocytosis and endocytosis
What is the sorting signal for lysosomal hydrolases?
M6P
Where part of the golgi is the Phosphate added and as well as attachment to M6P receptor?
On Trans Golgi
What are some of the properties of Lysosomes?
Highly acidic, filled with hydrolytic enzymes and filled with H+ ions
What is the process that attaches mannose to the lysosomal hydrolase?
Glycosylation
Addition of phosphate and signal patch occurs where?
GlcNAc phosphotransferase
What disease is due to aa mutation in the hydrolase that breaks down glycosaminoglycans?
Hurler’s Disease
What disease is the result of all of the lysosomal hydrolases missing and therefore undigested substrates are found in blood stream?
Inclusion Cell Disease
Cholesterol uptake is a form of?
Receptor-mediated endocytosis
Phagocytosis is carried out by ____ where as Pinocytosis is carried out by ____ and ____.
Phagocytes
Clathrin Coated Pits
Caveolae
Phagocytosis causes formation of ___ by changing actin structure via ___ and ___
pseudopod
Actin Polymerization
Reorganization
Pseudopod reorganization is controlled by ____ and ____
Rho GTPases and Phosphoinositide
One special thing about pinocytosis via caveolae is that _____
They do no connect with lysosomes
The SNARES on the synaptic vesicle are ___ and ___ (has Ca binding sites).
Synaptobrevin
Synaptotagmin
The SNARES on the plasma membrane are ___ and ___ (has Ca binding sites).
Syntaxin
SNAP25
