Transplantation Immunology Flashcards
1
Q
Allograft
A
to a genetically disparate member of the same species
2
Q
Autograft
A
to another site on the same individual (e.g. after burns)
3
Q
Hyperacute rejection
A
-Peformed antibodies directed against the donor tissue
-Caused by accidental ABO incompatibility
-Presents with occlusion and thrombosis of BV in surgery
Occurs within minutes to hours
4
Q
Acute rejection
A
T cell mediated immune response directed against the foreign MHC,
Inflammation and leukocyte infiltration of graft vessels
days/weeks
5
Q
Chronic rejection
A
Also T cell mediated process resulting from foreign
“MHC looking like” self MHC
vascular changes in graft
weeks/months/years
6
Q
What cells express ABO-antigens?
A
All stromal cells
7
Q
What is HLA?
A
The human MHC
