transplantation

Question 1

banff score components

Answer 1

vasculitis
tubulitis
interstitial inflammation
vti

Question 2

DSA what are they and how to detect

Answer 2

Antibodies specfic to donor HLA

luminex

Question 3

when is the induction treatment given

Answer 3

a little bit before Tx (high dose…more than maintenance)

Question 4

v3 criteria

Answer 4

fibrinoid necrosis or throughout the thickness

Question 5

changes in TCMR: where?

Answer 5

interstitial inflammation and parenchymal injury

Question 6

Tx for TCMR

Answer 6

steroids

give thymoglobulin if IB or more

Question 7

AMR changes location?

Answer 7

peritubular capillary and glomeruli (think of slow circulation)

Question 8

3 criteria for AMR

Answer 8

presence of DSA
immunological evidence (C4d)
morphologic evidence

Question 9

why C4d is used

Answer 9

long half life (2-3 weeks)

covalently bound to the tissue

Question 10

Rx of AMR

Answer 10

steroids
plasmapheresis
IVIG

Question 11

Strongst complement activating IgG subclass and which does not

Answer 11

IgG3 strongest (IgG1 can do too but not strong)
IgG4 cannot

Question 12

What is accommodation in kidney Tx

Answer 12

95% of ABO incompatilibity show presence of C4d eventhough there is no vegetation

Question 13

false negative staining for C4d is seen in

Answer 13

very severe rejection due to sloughing of endothelium

Question 14

4 pathways of compliment

Answer 14

classic
alternate
CRP
lectin