Glomerular Diseases Flashcards
membranous nephropathy means
immune mediated diseases of the membrane (complex i.e. granular or linear i.e. anti-GBM)
Common endogenous Ag for membranous nephropathy
PLA2R
3 layers of GBM
lamina densa
lamina rara externa
lamina rara interna
medicine to reduce progression of kidney disease
ACE I
nephrogenic strains of group A beta hemolytic strep
type 12, 4 and 1 (identified by typing of M protein)
Antigen causing PSGN
SpeB (streptococcal pyogenic exotoxin B)
a/c proliferative GN can be due to
post-streptococcal or other infections
in APGN, what proliferates
immune cells
mesangial cells
endothelial cells
APGN EM and IF
subepithelial hump
granular deposits in IF
crescents are const.by
parietal cells
monocytes
macrophages
GP disease. what is the Ag
alpha 3 chain of type IV collagen
3 types of RPGN
anti-GBM
Complication of IC deposit eg. PSGN
pauci-immune (ANCA pos granulomatosis with polyangitis)
EM picture of GBM in RPGN
wrinkling of GBM with focal disruptions
Types of FSGS
collapsing
tip
hilar
cellular
3 common causes of nephrotic syndrome
minimal change disease
membranous glomerulopathy
FSGS
2 less common causes of nephrotic syndrome
MPGN (membrano proliferative GN) type I and II
Others like IgA nephropathy
IgG subclass in primary membranous nephropathy
IgG4
Most characteristic HIV nephropathy
Collapsing FSGS
MPGN GBM and glomeruli description
tram track or splitting or duplication
lobular like brocolli
DM nephropathy think thick
thick GBM
Thick tubular BM
thick to become kimmelsteil wilson
spikes
membranous nephropathy
wire loop
SLE
IgA nephropathy where is the thickening?
mesangium
MPGN type II is aka
dense deposit disease
