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RenalPath > Glomerular Diseases > Flashcards

Glomerular Diseases Flashcards

1
Q

membranous nephropathy means

A

immune mediated diseases of the membrane (complex i.e. granular or linear i.e. anti-GBM)

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2
Q

Common endogenous Ag for membranous nephropathy

A

PLA2R

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3
Q

3 layers of GBM

A

lamina densa
lamina rara externa
lamina rara interna

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4
Q

medicine to reduce progression of kidney disease

A

ACE I

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5
Q

nephrogenic strains of group A beta hemolytic strep

A

type 12, 4 and 1 (identified by typing of M protein)

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6
Q

Antigen causing PSGN

A

SpeB (streptococcal pyogenic exotoxin B)

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7
Q

a/c proliferative GN can be due to

A

post-streptococcal or other infections

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8
Q

in APGN, what proliferates

A

immune cells
mesangial cells
endothelial cells

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9
Q

APGN EM and IF

A

subepithelial hump

granular deposits in IF

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10
Q

crescents are const.by

A

parietal cells
monocytes
macrophages

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11
Q

GP disease. what is the Ag

A

alpha 3 chain of type IV collagen

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12
Q

3 types of RPGN

A

anti-GBM
Complication of IC deposit eg. PSGN
pauci-immune (ANCA pos granulomatosis with polyangitis)

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13
Q

EM picture of GBM in RPGN

A

wrinkling of GBM with focal disruptions

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14
Q

Types of FSGS

A

collapsing
tip
hilar
cellular

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15
Q

3 common causes of nephrotic syndrome

A

minimal change disease
membranous glomerulopathy
FSGS

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16
Q

2 less common causes of nephrotic syndrome

A

MPGN (membrano proliferative GN) type I and II

Others like IgA nephropathy

17
Q

IgG subclass in primary membranous nephropathy

A

IgG4

18
Q

Most characteristic HIV nephropathy

A

Collapsing FSGS

19
Q

MPGN GBM and glomeruli description

A

tram track or splitting or duplication

lobular like brocolli

20
Q

DM nephropathy think thick

A

thick GBM
Thick tubular BM
thick to become kimmelsteil wilson

21
Q

spikes

A

membranous nephropathy

22
Q

wire loop

A

SLE

23
Q

IgA nephropathy where is the thickening?

A

mesangium

24
Q

MPGN type II is aka

A

dense deposit disease

RenalPath (2 decks)

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