Transplantation

Question 1

autologous graft

Answer 1

self

Question 2

syngeneic graft

Answer 2

identical twin

Question 3

allogeneic graft

Answer 3

another human (not twin)

Question 4

xenogeneic graft

Answer 4

one species to another

Question 5

alloantigens (or xenoantigens)

Answer 5

antigens that are the target of the rejection

Question 6

alloreactive and xenoreactive

Answer 6

Abs and T cells that react against the alloantigens or xenoantigens (“alloreactive T and B cells”)

Question 7

What are the MHC-I alleles and how many does each person have?

Answer 7

6:

HLA-A, B, C (one from each parent)

Question 8

What are the MHC-II alleles and how many does each person have?

Answer 8

6-8:
HLA DQ; DP (one from each parent)
HLA-DR (1 or 2 from each parent)

Question 9

Why are MHC molecules considered the main target antigens of allografts?

Answer 9

immunological cross reaction: some of the self-referential T cells may recognize and respond to forgein MHC from the donor graft as MHC-foreign peptide complex