transplant infx

Question 1

lymphocytic choriomeningitis virus

Answer 1

screen in donor

Question 2

why is serology less reliable in host

Answer 2

bc immune system is crap, ie no antibodies

Question 3

Autologous risk infection

Answer 3

High risk early on, prolonged PMN recovery

Question 4

allogeneic mini nonmyeloablative infection risk

Answer 4

low bc have PMNs

Question 5

Allogenic MURD infection risk

Answer 5

moderate

Question 6

Graft vs tumor effect

Answer 6

best allogenic unrelated
mod allogenic related
none autologous

Question 7

risk GVHD

Answer 7

auto low risk
allogeneic related (sibling), syngeneic (twin) low risk
MURD allogenic high risk
MURD PBSCT moderater

Question 8

Can cause meningitis

Answer 8

B cereus

Question 9

MC infx early on first few days

Answer 9

skin and gut organisms

Question 10

Risk of colitis from

Answer 10

C diff

Question 11

After a few days nosocomial are possible

Answer 11

XAMA, VRE, Acinetovacer ESBL, Nocardia

Question 12

Bradyrhizobium enteria

Answer 12

in cord blood cell recipients that can occur 90 - 300 days after transplantation.
Responds to metrinidazole

Question 13

Bugs >6mos post transplant

Answer 13

encapsulated organisms

esp if splenectomy or persisitne hypogammaglobulinemia

Question 14

Molds MC

Answer 14

Aspergillus, Rhizpus, fusarium, scedosporium, penicillium

this is why micafungin, vori and posa used for ppx

Question 15

Roseolavirus

Answer 15

HHV-6

Question 16

lipophillic

Answer 16

M furfur