sepsis

Question 1

sepsis

Answer 1

when infecctious etiology is provenor stronly suspected an the response results in hupofuntion of unifected organs

Question 2

septic shock

Answer 2

sepsis w/ hypotension cannot be corrected with fluids

Question 3

MD 2 TLR4

Answer 3

this moitey recognizes …. lipid A moitey = septic shock = ecoli, entc, kleb

Question 4

which bacteria poorly recognized by md 2 tlr4

Answer 4

Make lipid A with fewer than six acyl side chains 
y pestis
f tular
vibrio vuln
PSAR
b pseudomallei

these bacteria trigger little inflamation
if do trigger sepsis have to replicate to high numbers in the tissues and blood

Question 5

shielded LPS

Answer 5

N mening. shield by capsule. release large amounts of endotoxin and DNA

Question 6

what is a large determinant of sepsis

Answer 6

if the host can detect the bacterias lps

Question 7

rubor

Answer 7

increase blood flow to infected tissue

Question 8

calor

Answer 8

recruit PMN and other cells

Question 9

tumor

Answer 9

enhace permeability of local blood vssels

Question 10

dolor

Answer 10

elicit pain

Question 11

cytokines can exert

Answer 11

endocrine, paracrine, and autocrine effects

Question 12

TFN - alpha

Answer 12

stimulates leukocytes and vasular endothelial cells to release of the cytokines as well as additional TNF alpha
increase prostaglandin and leukotrient producions

Question 13

Is TNF alpha elevated with localized infections

Answer 13

no

Question 14

If TNF alpha elevated with sepsis and shock

Answer 14

yes

Question 15

Attract PMNs to the infection site

Answer 15

IL-8 and IL-17

Question 16

What is the benefit of clotting in sepsis

Answer 16

wall of the bacteria

Question 17

It activates coags

Answer 17

sepsis clotting activates intrinsic and extrinsic pathway

Question 18

which organism triggers dic most

Answer 18

n mening