Transplant

Question 1

What is the most important HLA antigens in matching?

Answer 1

A, B, DR (most important)

Question 2

What transplant does not require ABO compatability?

Answer 2

Liver

Question 3

What is mixed in a Cross Match?

Answer 3

Recipient serum with donor lymphocytes to check for pre-formed antibodies

Question 4

What is the sfx of MMF?

Answer 4

Myelosuppression (pancytopenia) and GI bleeding

Question 5

What are steroids used for in txp?

Answer 5

Induction, maintenance and acute rejection

Question 6

What are the sfx of cyclosporin?

Answer 6

Vomiting, seizures, arrhythmias

Hepatic metabolism, biliary excretion

Question 7

What is the difference between tacrolimus and cyclosporin?

Answer 7

Tacro with more Gi sx and mood sx but less entero-hepatic recirculation

Question 8

What is anti-thymocyte globulin used for?

Answer 8

Induction, acute rejection

Question 9

What is the main sfx of anti-thymocyte globulin?

Answer 9

Cytokine Release Syndrome (fevers, chills, edema, shock). Give steroids and Benadryl as pre-medication

Question 10

What are the main sfx of tacrolimus?

Answer 10

Nephrotoxicity and Neurotoxicity

Question 11

What are the main sfx of sirolimus?

Answer 11

Thrombocytyopenia and poor wound healing