Translocation Flashcards
Alveolar soft part sarcoma
t(X;17)(p11;q25) TFE3-ASPL fusion
Aneurysmal bone cyst
t(16;17)q22;p13) CDH11-USP6 fusion
Extraskeletal myxoid chondrosarcoma
t(9;22)(q22;q12)EWSR1-NR4A3 fusion;
t(9;17)(q22;q11)TAF2N-NR4A3 fusion;
t(9;15)(q22;q21)TCF12-NR4A3 fusion;
t(3;9)(q11;q22)TFG-NR4A3 fusion
Clear cell sarcoma
t(12;22)(q13;q12) EWSR1-ATF1 fusion
t(2;22)(q33;q12) EWSR1-CREB1 fusion
Desmoplastic small round cell tumor
t(11;22)(p13;q12) EWSR1-WT1 fusion
Dermatofibrosarcoma protuberans
DFSP
Ring form of chromosomes 17 and 22 COL1A1-PDGFB fusion
t(17;22)(q21;q13) COL1A1-PDGFB fusion
Ewing sarcoma/PNET
t(11;22)(q24;q12) EWSR1-FLI1 fusion
t(21;22)(q12;q12) EWSR1-ERG fusion
t(2;22)(q33;q12) EWSR1-FEV fusion
t(7;22)(p22;q12) EWSR1-ETV1 fusion
t(17;22)(q12;q12) EWSR1-E1AF fusion
inv(22)(q12;q12) EWSR1-ZSG fusion
t(16;21)(p11;q22) FUS-ERG fusion t(19;der)ins.inv(21;22) EWSR1-ERG fusion t(17;22)(q12;q12) EWSR1-ETV4 fusion
t(6;22)(p21;q12) EWSR1-POU5F1 fusion
t(1;22)(q36.1;q12) EWSR1-PATZ1 fusion
t(2;22)(q31;q12) EWSR!-SP3 fusion
t(20;22)(q13;q12) EWSR1-NFATC2 fusion
t(2;16)(q35;p11) FUS-FEV fusion
Infantile Fibrosarcoma
t(12;15)(p13;q26) ETV6-NTRK3 fusion Trisomies 8, 11, 17, and 20
Inflammatory myofibroblastic tumor
t(1;2)(q22;p23) TPM3-ALK fusion
t(2;19)(p23;p13) TPM4-ALK fusion
t(2;17)(p23;q23) CLTC-ALK fusion
t(2;2)(p23;q13) RANB2-ALK fusion
t(2;2)(p23;q35) ATIC-ALK fusion
t(2;11)p23;p15) CARS-ALK fusion
t(2;4)(p23;q21) SEC31L1-ALK fusion
t(2;12)(p23;p12) PPFIBP1-ALK fusion
Leiomyosarcoma
Complex with frequent deletion of 1p
Well differentiated liposarcoma
Ring form of chromosome 12
Amplification of MDM2, CDK4, and others
Myxoid/Round cell liposarcoma
t(12;16)(q13;p11) FUS-DDIT3 (CHOP)fusion
t(12;22)(q13;q12) EWSR1-DDIT3 (CHOP) fusion
Pleomorphic liposarcoma
complex
Low-grade fibromyxoid sarcoma
t(7;16)(q33;p11) FUS-CREB3L2 fusion
t(11;16)(p11;p11) FUS-CREB3L1 fusion
Malignant peripheral nerve sheath tumor
complex
Myxofibrosarcoma (myxoid MFH)
complex
Rhabdoid tumor
Deletion of 22q INI1(SMARCB1) inactivation
Alveolar Rhabdomyosarcoma
t(2;13)(q35;q14) PAX3-FOXO1A
fusion t(1;13)(p36;q14), double minutes PAX7-FOXO1A fusion
t(2 ;2)(q35 ;p23) PAX3-NCOA1 fusion t(X;2)(q35 ;q13) PAX3-AFX fusion
Embryonal Rhabdomyosarcoma
Trisomies 2q, 8 and 20
Loss of heterozygosity at 11p15
Solitary fibrous tumor
Inversion chromosome 12 NAB2-STAT6
Synovial sarcoma Monophasic
t(X;18)(p11;q11) SS18-SSX1, SS18-SSX2 or SS18-SSX4 fusion
Synovial sarcoma Biphasic
t(X;18)(p11;q11) Predominantly SS18-SSX1 fusion
Chondrosarcoma of bone
Complex; IDH1 and IDH2 mutations
Prostate cancer
ERG-TMPRSS2
Adult granulosa cell tumor
FOXL2
adenoid cystic carcinoma
T(6,9) myb-nfib
mucoepidermoid carcinoma
T(11,19) mect1-maml2
mammary analogue secretory carcinoma
T (12,15) etv6-ntrk3
clear cell hyalinizing carcinoma
T(12,22) ewsr1-atf1
NUT translocation carcinoma
t(15;19). BRD4-NUT
Pleomorphic adenoma
PLAG1 (c12) or HMGA2 (C8) rearrangement
Fibrolamellar HCC
DNAJB1-PRKACA
Sertoli leydig cell tumor
Dicer1
pulmonary htn
Bmpr2
LG endometrial stromal sarcoma
T(7;17) jazf1-suz12
HG endometrial stromal sarcoma
T(10;17) YWHAE-FAM22
Nodular fascitis
T(17;22) USP6-MYH9
