Hem

Question 1

Celiac disease associated cancer

Answer 1

NHL(B cell)
Adenocarcinoma
Enteropathy associated T cell lymphoma

Question 2

4 neoplastic cell types in FL

Answer 2

Small centrocytes, large centrocytes, small centroblasts, large centroblasts

Question 3

2 hematolymphoid malignancies associated with pure red cell aplasia (once pure red cell aplasia, look for giant normoblast-PVB19)

Answer 3

CLL

LGL

Question 4

Important elements in reviewing blood film for CLL

look for what?

Answer 4

Look for low plt-ITP

Look for low erythropoeisis-red cell aplasia

Question 5

flow CLL vs. mantle

Answer 5

CLL: CD19 dim, CD20 dim, kappa lambda equivocal
Mantle: CD19 bright, CD20 bright, light chain restriction (usually kappa)

Question 6

CyclinD1 positive hematolymphoid tumors:

Answer 6

Mantle cell lymphoma
Hairy cell leukemia
MM
(carcinomas!!!)

Question 7

Mantle cell lymphoma prognostic marker

Answer 7

Ki67

Question 8

2 diagnostic IHC markers for mantle

Answer 8

cyclinD1 and SOX11

Question 9

HHV8 related disease

Answer 9

Kaposi’s sarcoma
Castleman’s disease
Primary effusion lymphoma

Question 10

Lymphoma in which there is infection of all three of HIV/HHV8/HIV

Answer 10

Primary effusion lymphoma

Question 11

Castleman variants

Answer 11

Plasmacytic
hyaline vascular
plasmacytoid

Question 12

Castleman DDx (depending on histology)

Answer 12

IgG4 lymphadenopathy
Rheumatoid arthritis LAD
T cell lymphoma (AITL)
Small B cell lymphoma with plasma cell differentiation

Question 13

3 disease with plasmacytic monocytic cells

Answer 13

CMML
Castleman
Kikuchi

Question 14

5 T cell lymphomas that are usually CD8+

Answer 14

LGL
Enteropathy associated T cell lymphoma
Panniculitis like
Hepatosplenic
Extranodal NK

Question 15

What can CLL transform into (list 3)

Answer 15

DLBCL (Richter’s)
HL (Richter’s)
Prolymphocytic transformation

Question 16

CLL prognostic IHC marker

Answer 16

CD138