Translation Flashcards
What is the role of eIF4A?
It facilitates scanning of mRNA
Whats is the role of eIF4F?
To recruit pre-initiation complex
What is the role of eIF2?
It locks in at the AUG(start) codon
What is the role of eIFS?
It locks in the large subunit
What is the role of PABP?
Poly(A)Binding protein(PABP) stimulates the recruitment of the Initiation complex to the G-cap
What is the role of ATP in translation initiation?
Interacts with eIF4A to facilitate scanning
What is the role of GTP in translation initiation?
interacts with eIF2 to lock in at AUG and also interacts with eIFS to lock in the large subunit
What is the role of GTP in translation elongation?
Interacts with EF1-alpha for tRNA delivery and interacts with EF2 for translocation
What is the role of the large ribosomal subunit?
To catalyze the peptidyl transfer during elongation of the polypeptide
What is the role of GTP in translation termination?
Interacts with eRF3 to dissociate the ribosome complex