Translation Flashcards

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0
Q

What is the role of eIF4A?

A

It facilitates scanning of mRNA

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1
Q

Whats is the role of eIF4F?

A

To recruit pre-initiation complex

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2
Q

What is the role of eIF2?

A

It locks in at the AUG(start) codon

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3
Q

What is the role of eIFS?

A

It locks in the large subunit

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4
Q

What is the role of PABP?

A

Poly(A)Binding protein(PABP) stimulates the recruitment of the Initiation complex to the G-cap

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5
Q

What is the role of ATP in translation initiation?

A

Interacts with eIF4A to facilitate scanning

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6
Q

What is the role of GTP in translation initiation?

A

interacts with eIF2 to lock in at AUG and also interacts with eIFS to lock in the large subunit

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7
Q

What is the role of GTP in translation elongation?

A

Interacts with EF1-alpha for tRNA delivery and interacts with EF2 for translocation

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8
Q

What is the role of the large ribosomal subunit?

A

To catalyze the peptidyl transfer during elongation of the polypeptide

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9
Q

What is the role of GTP in translation termination?

A

Interacts with eRF3 to dissociate the ribosome complex

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