Transfusion therapy Flashcards
What is the universal donor
O
What is the universal receiver
AB
What factors may cause your antigens to change
Malignancy
thalassemia
What reaction occurs in the body if different antigens are infused
hemolysis (immune reaction)
What defines a mass transfusion
10+ units in 24 hours
What is the most commonly transfused product
PRBCs
(Packed RBCs)
What are packed red blood cells
Plasma is removed
*Used to raise hgb/blood volume
When are leukocyte reduced red blood cells used
Reduce risk of immune reaction
What are washed red blood cells and when are they used
They are washed with saline to remove residual plasma, WBCs, antibodies, and cytokines
Used to reduce incidence of transfusion reactions
What are frozen deglycerolized RBCs and why are they used
Glycerol added to PRBCs to protect against cell lysis
What are irradiated RBCs and what is their purpose
PRBCs subject to radiation
used to prevent allogenic immune reactions
What patient populations need irritated RBCs
Immunosuppressed
Stem cell / BM transplant
Intrauterine transfusion
Premies
1st degree relative donors
What is FFP
Fresh frozen plasma
*spun down from whole blood
What is the purpose of FFP
Provides coagulation factors
-vitamin K
-Factor 5
What are indications of using FFP
Abnormal PT/INR
coag factor deficiency
urgent warfarin reversal
