Transfusion Reactions clinical signs and lab findings Flashcards
Fever/chills, mild jaundice, anemia
Delayed hemolytic
fever, bleeding, tachycardia, hypotension, low back pain, dyspnea, hemoglobinuria, feeling of impending doom, death
Immediate Hemolytic
increased temp > or equal to 1’C or 2’F, chills
Febrile (non-hemolytic)
urticaria, pruritis, flushing
allergic
severe dyspnea, tachycardia, hypotension
anaphylactic
dyspnea, chills, fever, hypotension, chest rales, pulmonary edema, “white out”
TRALI
Dyspnea, cyano, chest rales, pulmonary edema, HYPERtension
TACO
rapid onset, sepsis/rigors, high fever immediately
bacterial contamination
thrombocytopenia
post-transfusion purpura
skin, GI system, bone marrow, hepatitis, dermatitis, enteritis
TA-GVHD
accumulation of iron affects function of heart, liver, and endo glands
Iron overload
LAB: DAT + , hemoglobinemia, increased bili and LDH, decreased haptoglobin, hemoglobinuria
Immediate Hemolytic
LAB: DAT + , IDAT + , spheres
Delayed hemolytic
Febrile (non-hemolytic), allergic, anaphylactic, TRALI, TACO, and TA-GVHD are ONLY DAT ________
Negative
LAB: product discolored, patient DAT neg, hemoglobinemia, hemoglobinuria, and culture product pos
Bacterial contamination