Transfusion reactions

Question 1

Excess volume causes high RAP & pulmonary edema

Answer 1

TACO

Question 2

Ab from plasma react with recipient lung tissue –> neutrophil infiltration, inflammation, and pulmonary edema

Answer 2

TRALI

Question 3

Allergens from blood crosslink IgEs present on recipient mast cells
- degranulate HM
- Symptoms

Answer 3

Allergic TR

Question 4

Ab binds recipient WBC and stimulates cytokine release; combined cytokines

Answer 4

FNHTR - Febrile non-hemolytic TR

Question 5

IgM binds RBCs and activates complement
- RBC lysis and some phagocytosis to kill RBCs

Answer 5

Acute hemolytic TR

Question 6

Acute pulmonary edema

Answer 6

TACO

Question 7

Acute respiratory distress syndrome
Pulmonary Edema

Answer 7

TRALI

Question 8

Hives, itching, occasionally anaphylaxix

Answer 8

Allergic TR

Question 9

Fever, chills, high respiratory rate, anxiety, high or low BP

Answer 9

Febrile

Question 10

Fever, chills, hypotension, hemolysis, renal damage

Answer 10

Acute HTR

Question 11

Prevent by slow transfusion

Answer 11

TACO

Question 12

Prevent by NOT accepting plasma

Answer 12

TRALI

Question 13

Prevent by washed cellular components

Answer 13

Allergic TR

Question 14

Prevent by Leukocyte reduction

Answer 14

Febrile

Question 15

Prevent by TS and match

Answer 15

Acute HTR

Question 16

Recipient has anti-ABO IgM in plasma that reacts with donor RBCs

Answer 16

Acute HTR

Question 17

Blood product contains anti WBC Ab and cytokines

Answer 17

Febrile

Question 18

Blood product contains allergens for that individual

Answer 18

Allergic TR

Question 19

Blood product contains anti-HLA Ab and anti-neutrophil Ab

Answer 19

TRALI

Question 20

Blood product volume

Answer 20

TACO

Question 21

Blood components are irradiated with gamma radiation to protect from

Answer 21

GVHD

Question 22

Patients with thrombocytopenia or abnormally functioning platelets

Answer 22

Platelet Transfusions

Question 23

______ components are prepared from one donor and must contain a minimum of 3 x 10(11) platelets.

Answer 23

Plateletpheresis

Question 24

Anticipated increases in platelet count: ___________

Answer 24

30,000 to 60,000/uL
(From Plateletpheresis)

Question 25

If the 10 minute increment platelet count increase is less than 50% of that expected on two occasions, the patient is considered _____

Answer 25

refractory

Question 26

Positive platelet XM and/or positive HLA antibody screen is considered evidence of ________

Answer 26

alloimmunization

Question 27

Washed RBCs are for

Answer 27

IgA deficient patients (Anaphylactic TR)

Question 28

Leukocyte-Reduced RBCs are used to reduce

Answer 28

HLA allo
CMV transmission
Febrile HTR
GVHD