Transfusion Medicine

Question 1

What is the risk or transmission of HIC, HCV, HBV in blood transfusion

Answer 1

1 in 500,000…this will be on test

Question 2

What is 1 unit of pbrc

Answer 2

250 ml of packed red blood cells…each unit raises Hb by 1 g/dl

Question 3

How long can prbc packs be stored?

Answer 3

42 days

Question 4

WHat happens after 42 days?

Answer 4

25% of transfued red cells will hemolyze after transfusion

Question 5

Type A allele transfers what sugar to the “O” antigen?

Answer 5

GalNac

Question 6

Type B transfers what sugar ?

Answer 6

Galactose

Question 7

Type “O” transfers what sugar?

Answer 7

None. The enzme is inactive in the “O” form.

Question 8

Two copies of A allele?

Answer 8

Type A blood

Question 9

Two copies of B allele?

Answer 9

Type B

Question 10

AB has both GalNac and Galactose

Answer 10

Yep

Question 11

What antibodies do type A ppl make?

Answer 11

B antibodies

Question 12

antibodies made by type B

Answer 12

A

Question 13

Antibodies by AB?

Answer 13

None

Question 14

What type of antibody is it?

Answer 14

IgM…fixes complement to th erecognized cell

Question 15

What does antigenicity mean?

Answer 15

Its kinda like a measure of how much of an antigen something is. It is defined as the likelihood of an antibody binding site to induce an antibody response.

Question 16

What is the most antigenic protein on red cell surface

Answer 16

RhD

Question 17

You understand how RhD works

Answer 17

Its easy. Treat with Rhogam after first pregnancy

Question 18

In who is it ok to transfer RhD+ blood to an RhD- pt?

Answer 18

old women and men. Never to women of childbearing age b/c they will develop an RhD antibody and can kill an RhD+ fetus.

Question 19

Why do we screen transfusion recipients for red cell minor antibodies?

Answer 19

These can react with minor red cell antigens. If you find the antibody, you can usually find blood without the antigen

Question 20

What is a crossmatch

Answer 20

Take doner blood and recipient blood and test for agglutination

Question 21

What do you give in an emergency blood transfusion?

Answer 21

O-

Question 22

Whats the lowest Hb level can healthy patients tolerate

Answer 22

7g/dl

Question 23

What are the 3 real reasons to transfer blood

Answer 23

Increased HR or RR along with confusion weakness.
Acute blood loss
During or immediately after an MI

Question 24

Mythical reasons to transfuse?

Answer 24

Old and frail
Asymptomatic coronary artery disease
To expand blood volume. NEVER, just use fluid
To promote wound healing. No doesn’t work

Question 25

What transfusion strategy is better and what are the target levels for each>

Answer 25

Liberal- 10-12 Hb

Restictive- 7-9…THIS IS BETTER