Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MOHD3 Exam 2 > Transfusion Medicine > Flashcards

Transfusion Medicine Flashcards

1
Q

Short half life
Expensive
Do not refrigerate

A

Platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Contents of cryoprecipitate

A

Factor 13
Fibrinogen
vWf + Factor 8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Given to limit chronic RBC transfusions

A

Erythropoietin: hematopoietic growth factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

GIven to avoid prolonged thrombocytopenia and risk of platelet transfusion

A

Romiplostim = thrombopoietin analogue: hematopoietic growth factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Desmopressin

A

Procoagulant

Releases von Willebrand factor from endothelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Recombinant Factor 7a

A

Procoagulant

Activator of extrinsic/common coagulation pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Prothrombin complex concentrates

A

Procoagulant

Vitamin K dependent clotting factors: Factor 2, 7, 9, 10, protein C, protein S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Factor 8, Factor 9 concentrates

A

Procoagulant

Specific factor replacement: Used in congenital and acquired hemophilia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Fibrin sealants

A

Procoagulant

Thrombin, fibrinogen, aprotinin, CaCl2 that promotes topical formation of fibrin on oozing surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Aprotinin

A

Antifibrinolytics

Protease inhibitor: inhibits fibrinolytic enzymes (plasmin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Tranexamic acid, episilon-aminocaproic acid

A

Antifibrinolytics

Competitively inhibit plasminogen conversion to plasmin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Immediate transfusion reactions

A

Hemolytic
Febrile
Allergic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Acute hemolytic transfusion reaction
Symptoms:

Labs:

A

Fever, chills, hypotension, chest/back pain

Positive Direct antiglobulin test
Increase LDH
Increased bilirubin, indirect
Low haptoglobin (remvoes free Hb from circulation)
Hemoglobinemia, hemoglobinuria 
Spherocytes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Delayed transfusion reactions

A

Hemolytic
Graft vs. Host disease
Iron overload
Transfusion transmitted virus/parasite/prions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Drop in Hb days-weeks after transfusion of RBC
Postitive direct antiglobulin test
Increased CONJUGATED bilirubin

A

Delayed hemolytic transfusion reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Transfusion associated GVHD caused by:

A

Infusion of T cells that recognize patient cells as foreign, but immunocompromised pt T cells don’t recognize donor cells as foreign

MOHD3 Exam 2 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions