Tranexamic Acid Flashcards
1
Q
Generic name
A
Tranexamic acid
2
Q
Trade name
A
Lysteda , Cyklokapron
3
Q
Class
A
Antifibrinolytic
4
Q
Mechanism of action
A
Forms a complex that displaces plasminogen from fibrin resulting in fibrinolysis
5
Q
Indications
A
Hemorrhagic shock
6
Q
Contraindications
A
Injury time >3 hours
Pregnancy
Known history of thromboembolic disease (DVT , PE , ETC)
Use of anticoagulants (warfarin, lovenox, etc)
Hemophilia
7
Q
Side effects / adverse reactions
A
Visual defects
Retinal venous and arterial occlusions
Thrombotic events
8
Q
Adult dose
A
Loading- 1 G in 50 ml NS over 10 minutes
Maintenance- 1 G over 8 hours
9
Q
Pediatric dose
A
Safety not established
10
Q
Drug interactions
A
Concurrent use of birth control increase risk of thromboembolic event
11
Q
Duration of action
A
Onset - 5-10 minutes
Peak - variable
Duration - 2-5 hours
