Traitement des cancers Flashcards

1
Q

Principaux effets secondaires du 5-FU?

A

• Cardiaque

- Aigu = SCA
- Chronique = CMD

• Syndrome main pied

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2
Q

Principaux effets secondaires des sels de platine?

A
  • Neurotoxicité (neuropathie périphérique)

- Nephro-toxicité

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3
Q

Principaux effets secondaires des ciclophosphamides?

A
  • Cystite hémorragique

- Carcinome épidemoïde de la vessie

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4
Q

Principaux effets secondaires des anthracyclines?

A
  • Cardiotoxicité (TDR, IC)
  • Leucémie secondaire
  • Veinotoxicité
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5
Q

Principaux effets secondaires des analogues de l’acide folique?

A

= MTX!

  • Nephrotoxicité
  • Hépatotoxicité
  • Fibrose pulmonaire
  • Cytopénies
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6
Q

Principaux effets secondaires de la bléomycine?

A
  • Fibrose pulmonaire
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7
Q

Principaux effets secondaires des alcaloïdes?

A
  • Neuropathie périphérique
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8
Q

Principaux effets secondaires des taxanes?

A
  • Neuropathie périphériques
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9
Q

CT donnant des effets secondaires cardiaques?

A
  • 5-FU

- Anthracycline

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10
Q

CT donnant des neuropathies?

A
  • Alcaloïdes
  • Taxanes
  • Sels de platine
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11
Q

CT donnant des effet secondaires néphrologiques?

A
  • Sels de platine

- Analogue de l’acide folique (MTX)

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12
Q

Effets secondaires communs aux chimiothérapies?

A

HADOCINS

  • Hématologiques (cytopénies, SMD)
  • Allergies
  • Digestifs (N/V, amaigrissement)
  • Onco = néoplasies induites
  • Cutanéo-phanériens = alopécie, mucite
  • Infectieux
  • Neurologiques = neuropathies périphériques
  • Stérilité = infertilité
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13
Q

Type pharmacologique des taxanes?

A
  • Poison du fuseau
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