Trachte drugs Flashcards
Sympathetic: ___?___- contract pupillary dilator muscle (? receptor)
mydriasis
a1
normally norepinephrine
Sympathetic or parasympathetic? Contract superior tarsal muscle to hold eyelid open. Receptor?
Sympathetic
a1
normally norepinephrine
Sympathetic or parasympathetic?: relax ciliary muscle for distant vision. Receptor? NT?
sympathetic
B2
epinephrine???
Sympathetic or parasympathetic? : Enhances aqueous humor formation via Beta receptor.
Sympathetic
Sympathetic or parasympathetic?: Inhibits aqueous humor formation via alpha2 receptor.
sympathetic
Sympathetic or parasympathetic?: focuses eye for near vision (ciliary muscle contraction). Receptor?
Parasympathetic
muscarinic
Sympathetic or parasympathetic? constricts pupil (miosis)-(pupillary sphincter contraction)-
receptor??
parasympathetic
muscarinic
Sympathetic or parasympathetic? Enhances drainage of aqueous humor (trabecular meshwork and canal of Schlemm). Recptor?
Parasympathetic
muscarinic
a1 adrenergic stimulant
used to dilate pupil
reverses ptosis in Horner’s syndrome
Phenylephrine (mydrifin)
a1 adrenergic stimulant
increases aqueous humor outflow and increase its production
epinephrine (epitrate)
used to dilate pupil to see if sympathetic innervation is in tact
prevent the reuptake of norepinephrine by blocking axoplasmic pumps
cocaine
reverses axoplasmic pump to push more norepinephrine out of the cell
used to dilate pupil to asses normal POST ganglionic nerve
amphetamine
muscarinic receptor antagonist
atropine
where are the muscarinic receptors in the eye (3 places)?
ciliary muscle contraction (zonules relax, lens fat, near vision focus)
pupilary sphincter contraction (constrict pupils)
trabecular network and canal of Schlemm drainage
Muscarinic agonist to see if parasympathetic nerves are working:
Pilocarpine
Two drugs preventing acetylcholine degradation:
Phisostigmine
Echothiophate
Two a1 receptor antagonists: (inhibit sympathetic NS)
Terazosin
Resperine
No pupilary response to cocaine means?
Horner syndrome–deficit of sympathetic nervous system
No pupillary response to amphetamine means?
No post-ganglionic nerve activity
Two things nicotine does:
- activates nicotinic receptors
2. activates parasympathetics to produce miosis (pupil constriction)
What does atropine do?
Muscarinic receptor ANTAGONIST –>dliates pupil (mydriasis)
also paralyzes ciliary muscle so can’t accommodate near focusing
What does pilocarpine do?
What is it used for?
muscarinic agonist (parasympathetic)
test for CN III palsy: if pupil constricts then problem is in nerve
if it doesn’t constrict then problem is in eye
Physostigmine?
prevents Ach degradation
produces miosis
treats narrow angle glaucoma
Ecothiophate?
prevents Ach degradation
produces miosis (pupil constriction)
used to treat narrow angle glaucoma
