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CRAAB 6 > Trachte: Adrenergic Agonists > Flashcards

Trachte: Adrenergic Agonists Flashcards

1
Q

What is NE synthesized from?

A

Tyrosine

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2
Q

What acts on B1 receptors?

A

Isoproterenol> Epi = NE

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3
Q

Where are B1 receptors located?

A

Heart
JG apparatus
Adipose tissue

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4
Q

What does stimulation of B1 receptors lead to?

A

Galpha>
increase cAMP>
adrenergic cardiac effects, renin release

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5
Q

What acts on A1 recetpors?

A

Epi> NE» Iso

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6
Q

Where are A1 receptors located and what do they do?

A

blood vessels>

Smooth muscle contraction

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7
Q

What g protein are A1 receptors coupled to?

A

Galpha a>
phospholipiase C>
inositol triphosphates>
increase intracellular CA

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8
Q

What acts on B2 receptors?

A

iso> epi» NE

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9
Q

What does stimulation of B2 receptors do?

A

relax smooth muscle

metabolic effects

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10
Q

Where are B2 receptors located?

A

Blood vessels (smooth muscle)

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11
Q

What G protein are B2 receptors coupled with?

A

G alpha s>

increase c AMP

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12
Q

What acts on A2 receptors?

A

Epi> NE» Iso

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13
Q

What does stimulation of A2 receptors do?

A

Inhibits NE release

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14
Q

Where are A2 receptors locate?

A

Prejunctional nerve terminal, platelets, gut, medulla oblongata

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15
Q

How do A2 receptors decrease cAMP?

A

G aplha i>

decrease cAMP or activate Na/H antiporter

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16
Q

What do dopaminergic receptors interact with? What does this do?

A

DA

dilate renal and mesenteric vasculature

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17
Q

What is Dobutamine?

A

B1 agonist

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18
Q

What does Dobutamine do to blood pressure and what will block that effect?

A

INCREASE BP

Blocked by propranolol

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19
Q

What is dobutamine used for?

A

CHF

AMI w/ heart failure

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20
Q

What is phenylphrine?

A

alpha 1 agonists

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21
Q

What is phenylphrine used for?

A

reverse hypotension

paroxysmal atrial tachycardia

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22
Q

What is used to treat orthostatic hypotension?

A

Midodrine

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23
Q

What does phenylphrine do to blood pressure? What blocks it?

A

Increases blood pressure

Blocked by Terazosin

24
Q

What receptor does Metaprotenrenol, Terbutaline, Albuterol and Salmeterol act on?

A

B2 selective agonist

25
Q

What is albuterol used for?

A

Bronchodilation

Asthma- B2 agonists

26
Q

What drugs are used to delay labor?

A

ritodrineterbutaline

27
Q

What are side effects of B1 stimulatoin

A

Tachycardia, palpitations

28
Q

What are side effects of B2 stimulation?

A

tremor and headache

29
Q

What is the major cardiovascular effect to iv injection of a B2 selective agonist?

A

Vasodilation

30
Q

What does albuterol do to blood pressure? What would block that action?

A

Decreases blood pressure

Propranolol

31
Q

Whatare Clonidine, methyldopa, guanabenz and tizanidine?

A

A2 agonists

32
Q

What is an antihypertensive that’s safe to use in pregnancy?

A

Methyldopa

33
Q

What drugs decrease sympathetic activity without interfering with reflexes?

A

Guanabenz, Guanfacine

34
Q

What is clonidine used for?

A

ADD

35
Q

What are side effects of A2 receptor agonists?

A

Depression
Sexual dysfunction
Dry mouth
bradycardia

36
Q

What do alpha 2 agonists do to blood pressure?

A

Increase blood pressure

37
Q

What happens when Epi stimulates A1 vs B2?

A

A1- vasoconstricts

B2- vasodilate

38
Q

What does Epi do in the cardiovascular system?

A

INCREASES HR and force but reflexes to elevation in BP can suppress HR (vagal stimulation)

39
Q

What does Epi do to blood pressure?

A

Increases blood pressure

40
Q

What happens when EPI is blocked by terazosin?

A

Brings blood pressure back to normal

41
Q

What happens if you give Epi and terazosin?

A

Decrease BP

42
Q

What happens when you give epi after giving terazosin and propranolol?

A

BP stays the same

43
Q

What does NE do?

A

A1- vasoconstriction
B1- increase heart rate and force

(reflex reduction in HR–mediated by vagus nerve)

44
Q

What does NE do to bp?

A

Increases BP

45
Q

What happens if you administer NE after giving terozosin?

A

Smaller increase in BP

46
Q

What happens if you give NE after giving terazosin and propranolol?

A

Bp stays the same

47
Q

What does isoproternol do?

A

B2- vasodilation

B1- tachycardia

48
Q

What is isoproterenol used for?

A

B1 cardiac stimulation

49
Q

Stimulation of what receptor increases CO?

A

B1

50
Q

Stimulation of what receptor increases TPR?

A

B1, A1

51
Q

Stimulation of what receptor decreases HR?

A

Muscarinic

52
Q

Stimulation of what receptor decreases TPR?

A

Muscarinic and B2

53
Q

What does affect does dopamine have on B1, dopaminergic, A1 and the neural system?

A

B1- positive ionotrope
Dopaminergic- vasodilator of renal and mesenteric vasculature
A1- vasoconstrictor at high doses
Neural- releases NE from nerves

54
Q

What is DA used for?

A

Maintains renal perfusion
Hypotension
Increased BP and CO

55
Q

What do indirectly acting agents (like NE and Amphetamine) do?

A

Release NE from nerves by reversing the catecholamine axoplamic uptake pump>
increases BP

CRAAB 6 (9 decks)

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