Trachte: Adrenergic Agonists

Question 1

What is NE synthesized from?

Answer 1

Tyrosine

Question 2

What acts on B1 receptors?

Answer 2

Isoproterenol> Epi = NE

Question 3

Where are B1 receptors located?

Answer 3

Heart
JG apparatus
Adipose tissue

Question 4

What does stimulation of B1 receptors lead to?

Answer 4

Galpha>
increase cAMP>
adrenergic cardiac effects, renin release

Question 5

What acts on A1 recetpors?

Answer 5

Epi> NE» Iso

Question 6

Where are A1 receptors located and what do they do?

Answer 6

blood vessels>

Smooth muscle contraction

Question 7

What g protein are A1 receptors coupled to?

Answer 7

Galpha a>
phospholipiase C>
inositol triphosphates>
increase intracellular CA

Question 8

What acts on B2 receptors?

Answer 8

iso> epi» NE

Question 9

What does stimulation of B2 receptors do?

Answer 9

relax smooth muscle

metabolic effects

Question 10

Where are B2 receptors located?

Answer 10

Blood vessels (smooth muscle)

Question 11

What G protein are B2 receptors coupled with?

Answer 11

G alpha s>

increase c AMP

Question 12

What acts on A2 receptors?

Answer 12

Epi> NE» Iso

Question 13

What does stimulation of A2 receptors do?

Answer 13

Inhibits NE release

Question 14

Where are A2 receptors locate?

Answer 14

Prejunctional nerve terminal, platelets, gut, medulla oblongata

Question 15

How do A2 receptors decrease cAMP?

Answer 15

G aplha i>

decrease cAMP or activate Na/H antiporter

Question 16

What do dopaminergic receptors interact with? What does this do?

Answer 16

DA

dilate renal and mesenteric vasculature

Question 17

What is Dobutamine?

Answer 17

B1 agonist

Question 18

What does Dobutamine do to blood pressure and what will block that effect?

Answer 18

INCREASE BP

Blocked by propranolol

Question 19

What is dobutamine used for?

Answer 19

CHF

AMI w/ heart failure

Question 20

What is phenylphrine?

Answer 20

alpha 1 agonists

Question 21

What is phenylphrine used for?

Answer 21

reverse hypotension

paroxysmal atrial tachycardia

Question 22

What is used to treat orthostatic hypotension?

Answer 22

Midodrine

Question 23

What does phenylphrine do to blood pressure? What blocks it?

Answer 23

Increases blood pressure

Blocked by Terazosin

Question 24

What receptor does Metaprotenrenol, Terbutaline, Albuterol and Salmeterol act on?

Answer 24

B2 selective agonist

Question 25

What is albuterol used for?

Answer 25

Bronchodilation Asthma- B2 agonists

Question 26

What drugs are used to delay labor?

Answer 26

ritodrineterbutaline

Question 27

What are side effects of B1 stimulatoin

Answer 27

Tachycardia, palpitations

Question 28

What are side effects of B2 stimulation?

Answer 28

tremor and headache

Question 29

What is the major cardiovascular effect to iv injection of a B2 selective agonist?

Answer 29

Vasodilation

Question 30

What does albuterol do to blood pressure? What would block that action?

Answer 30

Decreases blood pressure | Propranolol

Question 31

Whatare Clonidine, methyldopa, guanabenz and tizanidine?

Answer 31

A2 agonists

Question 32

What is an antihypertensive that's safe to use in pregnancy?

Answer 32

Methyldopa

Question 33

What drugs decrease sympathetic activity without interfering with reflexes?

Answer 33

Guanabenz, Guanfacine

Question 34

What is clonidine used for?

Answer 34

ADD

Question 35

What are side effects of A2 receptor agonists?

Answer 35

Depression Sexual dysfunction Dry mouth bradycardia

Question 36

What do alpha 2 agonists do to blood pressure?

Answer 36

Increase blood pressure

Question 37

What happens when Epi stimulates A1 vs B2?

Answer 37

A1- vasoconstricts | B2- vasodilate

Question 38

What does Epi do in the cardiovascular system?

Answer 38

INCREASES HR and force but reflexes to elevation in BP can suppress HR (vagal stimulation)

Question 39

What does Epi do to blood pressure?

Answer 39

Increases blood pressure

Question 40

What happens when EPI is blocked by terazosin?

Answer 40

Brings blood pressure back to normal

Question 41

What happens if you give Epi and terazosin?

Answer 41

Decrease BP

Question 42

What happens when you give epi after giving terazosin and propranolol?

Answer 42

BP stays the same

Question 43

What does NE do?

Answer 43

A1- vasoconstriction B1- increase heart rate and force (reflex reduction in HR--mediated by vagus nerve)

Question 44

What does NE do to bp?

Answer 44

Increases BP

Question 45

What happens if you administer NE after giving terozosin?

Answer 45

Smaller increase in BP

Question 46

What happens if you give NE after giving terazosin and propranolol?

Answer 46

Bp stays the same

Question 47

What does isoproternol do?

Answer 47

B2- vasodilation | B1- tachycardia

Question 48

What is isoproterenol used for?

Answer 48

B1 cardiac stimulation

Question 49

Stimulation of what receptor increases CO?

Answer 49

B1

Question 50

Stimulation of what receptor increases TPR?

Answer 50

B1, A1

Question 51

Stimulation of what receptor decreases HR?

Answer 51

Muscarinic

Question 52

Stimulation of what receptor decreases TPR?

Answer 52

Muscarinic and B2

Question 53

What does affect does dopamine have on B1, dopaminergic, A1 and the neural system?

Answer 53

B1- positive ionotrope Dopaminergic- vasodilator of renal and mesenteric vasculature A1- vasoconstrictor at high doses Neural- releases NE from nerves

Question 54

What is DA used for?

Answer 54

Maintains renal perfusion Hypotension Increased BP and CO

Question 55

What do indirectly acting agents (like NE and Amphetamine) do?

Answer 55

Release NE from nerves by reversing the catecholamine axoplamic uptake pump> increases BP