Trachte Flashcards
loop diuretics
furosemide
bumetanide
loop diuretics mech
- block Na/K/2Cl transport in ascending limb of loop of Henle
- accounts for 25% Na reabsorption
- dramatically increases Na, K, and H20 EXCRETION
thiazide diuretic
chlorthalidone
hydrochlorathiazide
metalozone
thiazide diuretic mech
- block Na/Cl transport in distal convoluted tubule
- accounts for 8% Na reabsorption
- MILDER increase in Na and K EXCRETION (than loop diuretics)
potassium sparing diuretics
spironolatcone
eplerenone
amiloride
triamterene
potassium sparing diuretics mech
- block ALDO receptors (spironolactone and eplerenone)
- block the Na exchange for K and H (amiloride and triamterene)
- MILD diuretics, primarily prevent excessive K wasting = block exchange of Na/K in collecting tubule
ADH and desmopressin
- increase aquaporin channels in collecting duct
- allows CONCENTRATION OF URINE
osmotic diuretics
mannitol
osmotic diuretic mech
exert osmotic effect in proximal tubule to REDUCE H2O REABSORPTION
SGLT-2 inhibitors
canigliflozin
SGLT-2 inhibitors mech
- reduces glucose reabsorption
carbonic anhydrase inhibitors
acetazolamide
carbonic anhydrase inhibitor mech
- block the reabsorptive processes in proximal tubule
- major utility in glaucoma or excess CSF production or urinary alkalinization
probenicid
sulfinpyrazone
- suppress uric acid reabsorption in gout
microtubule inhibitor in gout
colchicine
- suppress uric acid reabsorption in gout