Trace Minerals Flashcards
What are the two types of trace elements?
Metals (e.g., Selenium)
Halogens (e.g., Fluoride, Iodine)
What essential roles do trace elements play in the body?
Maintain health and tissue functions
Perform unique metabolic roles
What is the typical concentration of trace elements in the body?
Wet tissue: Less than 1 µg/g
Dry body weight: Less than 0.01%
What trace element enhances insulin action and supports glucose and lipid metabolism?
Chromium
What conditions can result from chromium deficiency?
Insulin resistance
Impaired glucose tolerance (Type II Diabetes Mellitus)
Hyperlipidemia
What are the toxic effects of chromium?
Skin ulcers
Renal and hepatic necrosis
What trace element supports hemoglobin synthesis and is a component of vitamin B12?
Cobalt
What conditions can result from cobalt deficiency?
Anemia
Growth depression
What toxic effects are associated with cobalt?
Heart failure
Hypothyroidism
What trace element is essential for cellular respiration and collagen synthesis?
Copper
What disease is caused by copper deficiency?
Menkes disease
What effect does excess copper have on nutrient absorption?
Interferes with iron and zinc absorption
What condition is characterized by sparse, kinky hair, failure to thrive, and nervous system deterioration?
Menkes disease
What genetic mutation causes Menkes disease?
ATP7A gene mutation, which disrupts copper transport
How is Menkes disease diagnosed?
Brittle, sparse, tangled hair
Low serum copper and ceruloplasmin levels
What trace element reduces pain, protects against gum disease, and prevents tooth decay?
Fluoride
What is the primary function of fluoride?
Prevention of dental caries
What condition results from fluoride deficiency?
Dental caries
What trace element is essential for thyroid hormone synthesis (T3, T4)?
Iodine
What conditions can result from iodine deficiency?
Goiter
Cretinism
Myxedema
What condition results from excessive iodine intake?
Thyrotoxicosis
What trace element is essential for oxygen transport and is a key component of hemoglobin?
Iron
What condition results from iron deficiency?
Iron deficiency anemia
What condition results from excessive iron accumulation?
Hemochromatosis