Toxins

Question 1

Diptheria toxin and Psudo Enterotoxin A

Answer 1

ADP ribosylate EF-2, causing inhibition of protein synthesis

Question 2

Shiga Toxin from Shigella or E.coli

Answer 2

RNA N-glycosidases 60s

Question 3

Enterotoxins E.coli and Cholerae

Answer 3

Increase Gs which increases cAMP which causes fluid loss (diarrhea)

Question 4

Pertussis toxin

Answer 4

Inhibits Gi in phagocytic cells which increases cAMP which causes decreased phagocytosis

Question 5

Heat Stable Enterotoxin I in E.coli

Answer 5

Acts as guanylate cyclase which increases cAMP which causes fluid loss (diarrhea)

Question 6

Anthrax Edema Factor and Pertussis adenylate cyclase toxin

Answer 6

Cuases increase in cAMP but needs calmodulin and Calcium from cell

Question 7

Anthrax lethal factor

Answer 7

Cleave a particular MAP kinase kinase protein, inhibiting MAP kinase signaling

Question 8

C. diff toxins A and B

Answer 8

inactivate cytoskeletons

Question 9

What type of neurons does botulinum toxin act on?

Answer 9

Motor Neurons

Question 10

What type of neurons does tetanus toxin act on?

Answer 10

Interneurons

Question 11

What bacteria cause superantigens?

Answer 11

Strep A and Strep pyogenes