Drugs

Question 1

What are the -cidal mechanisms?

Answer 1

Cell wall synthesis inhibitors
DNA synthesis inhibitors
Cell membrane function inhibitors

Question 2

What are the -static mechanisms?

Answer 2

Protein synthesis inhibitors

Intermediate metabolism inhibitors

Question 3

Non-renal excretion

Answer 3

Doxycycline
Quinolones
Clindamycin - (Cipro is renally eliminated but is an inhibitor of P450)
Rifampin - (Inducer of P450)
Isoniazid - (genetic polymorphism, potential for hepatotoxicity)
Metronidazole - (drug interaction with alcohol, inhibition of aldehyde metabolism)
Erythromycin-like - (inhibition of P450)
Sulfonamides - (concern for renal crystalluria)

Question 4

What are the first generation cephlosporins?

Answer 4

Cefazolin, Cephalexin

Question 5

What are the third generation cephlosporins?

Answer 5

Ceftriaxone

Question 6

What are the four carbapenems?

Answer 6

Ertapenem
Imipenem-cilastatin
Meropenem
Doripenem

Question 7

What are the three macrolides?

Answer 7

Erythromycin
Clarithromycin
Azithromycin

Question 8

What are the protein synthesis inhibitors?

Answer 8

Macrolides
Tetracyclines
Clindamycin
Chloramphenicol
Aminoglycosides

Question 9

What are the DNA inhibitors?

Answer 9

Fluoroquinolones (Ciprofloxacin, Levofloxacin, Moxifloxacin)
Nitrofurantoin
Metronidazole