Toxicology abstracts Flashcards
What was the objective of the study on bromethalin ingestion in dogs?
Scotti et al
JVECC 2021
To evaluate the frequency of clinical signs, dose ingested, and outcome in a large group of dogs with bromethalin ingestion.
What percentage of dogs developed clinical signs after bromethalin ingestion?
Scotti et al
JVECC 2021
Approximately 13% (25 out of 192 dogs).
What was the median dose ingested by the dogs in the bromethalin study?
Scotti et al
JVECC 2021
0.2 mg/kg.
What treatment was most commonly used for dogs with bromethalin ingestion?
Scotti et al
JVECC 2021
Decontamination, including emesis and activated charcoal.
What were the most common clinical signs reported in dogs with bromethalin ingestion?
Scotti et al
JVECC 2021
- Vomiting
- Tremors
- Lethargy
- Ataxia
- Weakness
- Diarrhea
- Collapse
- Anorexia
What was the prognosis for dogs that developed severe clinical signs after bromethalin ingestion?
Scotti et al
JVECC 2021
Poor, with a high euthanasia rate.
What was the purpose of the study comparing hair element concentrations in epileptic and healthy dogs?
Rosendahl et al
JVIM 2023
To compare hair element concentrations in dogs with idiopathic epilepsy and healthy controls.
What trace elements were found to be significantly different in dogs with idiopathic epilepsy compared to healthy controls?
Rosendahl et al
JVIM 2023
- Lower hair phosphorus
- Higher hair copper
- Higher hair zinc
- Higher selenium
- Higher arsenic
What treatment was associated with high hair arsenic levels in epileptic dogs?
Rosendahl et al
JVIM 2023
Potassium bromide treatment.
What were the common clinical signs observed in dogs with acute organophosphate or carbamate intoxication?
Klainbart et al
Vet J 2019
- Muscle tremor
- Hypersalivation
- Miosis
- Weakness
- Vomiting
- Diarrhea
What was the mortality rate reported in the study of acute organophosphate or carbamate intoxication?
Klainbart et al
Vet J 2019
17%.
What common laboratory abnormalities were observed in dogs with organophosphate or carbamate intoxication?
Klainbart et al
Vet J 2019
- Decreased butyrylcholine esterase activity
- Acidemia
- Increased total plasma protein
- Leukocytosis
- Hypochloridemia
What treatment was significantly associated with survival in dogs treated for organophosphate or carbamate intoxication?
Klainbart et al
Vet J 2019
Gastric lavage.
What is intermediate syndrome (IMS) in the context of anticholinesterase pesticide intoxication?
Klainbart et al
Vet J 2022
A condition that occurs 7–96 hours following an acute cholinergic crisis, manifesting as weakness of proximal limb, respiratory, and neck flexor muscles.
What percentage of dogs diagnosed with anticholinesterase intoxication progressed from acute cholinergic crisis to intermediate syndrome?
Klainbart et al
Vet J 2022
22% (7 out of 32 dogs).
What was the survival rate for dogs diagnosed with intermediate syndrome?
Klainbart et al
Vet J 2022
100%.
What clinical signs suggest the presence of intermediate syndrome in dogs?
Klainbart et al
Vet J 2022
- Respiratory muscle weakness
- Neck muscle weakness
- Proximal limb muscle paresis or paralysis
True or False: The absence of clinical signs consistent with acute cholinergic crisis excludes the possibility of intermediate syndrome.
Klainbart et al
Vet J 2022
False.
