Toxicology

Question 1

isopropyl alcohol (isopropanol) ingestion

Answer 1

alcohol dehydrogenase converts isopropanol to acetone (a ketone), which does not require Bicarb(therefore no metabolic acidosis).

• osmolal gap: lab - calc
• calc: 2xNa + BUN/2.8 + Glucose/18
• normal gap: 10
• if increased, there are unmeasured osms (ethanol, methanol, isopropyl alcohol, ethylene glycol)
• methanol (met acidosis, retinal abnorm)
• ethylene glycol (met acidosis, kidney failure)
• hypokalemia (toluene)