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Pharm block 8 > toxicology > Flashcards

toxicology Flashcards

1
Q

most exposures occur where

A

at home, in the kitchen

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2
Q

most common overall exposure

A

analgesics

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3
Q

most common exposure in kids

A

cosmetics, personal care items

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4
Q

most adult fatalities are associated with-

A

intentional ingestion

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5
Q

most common intervention-

A

decontamination

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6
Q

first step in management

A

ABCDE (including to eliminate the exposure)

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7
Q

Identify the toxin that causes:

coma, miosis, respiratory depression

A

narcotics

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8
Q

Identify the toxin that causes:

dry skin, decreased sweating, mydriasis, fever, confusion, urinary retention

A

anti-cholinergic

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9
Q

Identify the toxin that causes: salivation, lacrimation, diarrhea, emesis, urination

A

cholinergic (like sarin gas)

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10
Q

Identify the toxin that causes: dystonia

A

antipsychotics

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11
Q

suspect MetHb when-

A

central cyanosis that does not improve with 100% O2

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12
Q

treatment for MetHb

A

methylene blue

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13
Q

rapid development of non-cariogenic pulmonary edema with-

A

heroin

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14
Q

cholinergic antidote

A

atropine +2-PAM

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15
Q

antipsychotic antidote

A

benztropine

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16
Q

cyanide antidote (3)

A

sodium thiosulfate
sodium nitrate
hyroxocobalamin

17
Q

digoxin antidote

18
Q

methanol/ethylene glycol antidote (2)

A

ethanol

fomepizole

19
Q

benzo antidote

A

flumazenil

20
Q

acetaminophen antidote

A

N-acetylcysteine

21
Q

opiate antidote

22
Q

anti-cholinergic antidote

A

physostigmine

23
Q

heparin antidote

A

protamine sulfate

24
Q

warfarin antidote

25
Q

INH seziures antidote

A

pyridoxine

26
Q

lead chelator

27
Q

iron chelator

A

deferoxamine

28
Q

arsenic, gold, mercury chelator

A

dimercaprol (BAL)

29
Q

copper chelator

A

d-penicillamine

30
Q

peak hepatotoxicity in acetaminophen OD

A

72-96 hours

31
Q

lead inhibits:

A

d-ALA hydratase

ferrochelatase

32
Q

acute lead exposure sign

A

acute abdominal pain

33
Q

test for chronic/intermittent lead exposure

34
Q

cadmium has a

35
Q

most sensitive indicator of serious iron poisoning

36
Q

mees lines are seen in-

A

arsenic poisoning

37
Q

brain finding in CO poisoning

A

bilateral necrosis of globus pallidus

38
Q

CN binds to

A

cytochrome c oxidase (complex IV)

Pharm block 8 (3 decks)

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