Toxicology

Question 1

Acetaminophen Toxicity (Tylenol) symptoms

Answer 1

Stage 1: Malaise, RUQ pain (0-24 hours)
Stage 2: Elevated liver labs (18-72 hrs)
Stage 3: Maximal liver injury (72-96hrs)
Stage 4: Recovery (4-21 days)

Question 2

Cure for Acetaminophen Toxicity

Answer 2

N-Acetylcysteine
Binds with toxic metabolites of acetaminophen
Given within 8-10 hrs

Question 3

Acetylsalicylic acid toxicity (Aspirin)

Answer 3

No antidote
Treatment:
ICU: Sodium bicarbonate
Hemodialysis

Question 4

Beta-blocker cause hyper/hypoglycemia?

Answer 4

Hypoglycemia

Question 5

Calcium Channel blocker cause hyper/hypoglycemia?

Answer 5

Hyperglycemia

Question 6

Flumazenil

Answer 6

Competitive antagonist for benzo OF
May cause withdrawals (concerns for seizures)

Question 7

Toxic Alcohol poisoning

Answer 7

Hallmark sign is WIDE GAP METABOLIC ACIDOSIS

Question 8

Methanol

Answer 8

Wood alcohol

Question 9

Ethylene Glycol

Answer 9

Antifreeze
Calcium oxalate crystals found in brain, heart, and lung tissues

Question 10

Isopropanol

Answer 10

Rubbing Alcohol
Direct effect on Organ tissues

Question 11

Treatment of Toxic Alcohols

Answer 11

Administration of ethanol alcohol or Fomepizole

Question 12

Beer Potomania

Answer 12

Dilutional hyponatremia from drinking too much beer

Question 13

TCA OD

Answer 13

Wide QRS
Hyperthermia with impaired sweating
Hypotension

Question 14

Digitalis poisoning

Answer 14

GI distress is usually first sign
May see green or yellow halos
EKG changes:
-Slowing heart rate
- ST depression “ice cream scoop”

Treatment: Digibind