Toxicology Flashcards
How does black widow cause paralysis?
Acetylcholine binds Ca channels
How does warfarin tox work?
Anticoagulant (2,7,9,10)
Prolongs PT
What is brodifacoum?
Vitamin K antagonist
Cholecalciferol toxicity
Fatal hypercalcemia
Increased phosphorus
Bromethalin toxicity
CNS
Treatment for ethylene glycol
4-MP or ethanol
Organophosphate toxicity
Inhibits acetylcholinesterase
Hypersalivate, bloat
Treatment for organophosphate tox
Atropine or 2-PAM
Strychnine MA
Glycine antagonist
Get tremors
Strychnine treatment
Methocarbomol
Lillies that accumulate calcium oxalate
Peace and cala
What does red maple leaf tox in horses cause
Heinz body anemia
Slaframine (moldy red clover)
Slobbers
Cantharadin in horses
Colic
Cardio shock
Hematuria
Ergot tox in horses
Alkaloids
Thrombosis
Colic
Yellow star thistle toxicity
Nigropalladial myelomalacia
Loss of prehension
Grave prognosis
Locoweed (swainsonine) toxicity
Behavior change
Abortion
Fescue tox in horses
Ergopeptine alkaloids—dopamine agonist
Repro failure in nares
Prolactin suppression
Hoof sloughing
Bracken fern toxicity
Marrow suppression
Enzootic hematuria
Polioencephalomalacia in horses
Milkweed, gossypol, oleander, etc toxicity
Acute death
Arrhythmias
Ionophore tox in horses
Myocardial necrosis
DCM
Hemoglobinuria
Perilla mint toxicity
Dyspnea
Frothing at mouth
Causative agents of fog fever
Brassica plants
Tryptophan to 3-MI
Lush forage
Moldy sweet potatoes (fusarium)
4-IP
Grunt, cough, distress
Examples of pyrrolizidine alkaloids
Fiddleneck
Groundsel
Ragwort
Senecio
Larkspur
Pyrrolizidine alkaloid effects (liver)
Inhibit hepatocyte mitosis
Megalocytosis, peripheral fibrosis, bile duct hyperplasia
Pyrrolizidine alkaloid effects (other)
Secondary photosensitization
Primary photosensitization—St Johns Wort, Brassica, Hypericum
