Toxicities Flashcards
Which drugs increase the risk of Leukemia
alkylating agents
Which drugs cause hepatotoxicity?
- methotrexate
- 6 MP
- Nitolinib
Which drugs cause pulmonary fibrosis?
- carmustine and lomustine
- bleomycin
- dasatinib (pulmonary hypertension)
Which drugs cause nephrotoxicity?
- Cisplatin
- Methotrexate
- carmustine and lomustine
Which drugs cause neuropathies?
- cisplatin
- oxaliplatin (cold induced)
- taxanes
- vincristine
Which drugs cause cardiotoxicity?
- anthracyclines
- 5FU
- Vefuramenib and Nilotinib (QT prolongation)
- Trastuzumab (ventricular dysfunction)
- cetuximab
Which drugs cause hemorrhagic cysts?
cyclophosphamide and ifosphamide
Which drug causes thrombocytopenia?
carboplatin
Which drugs cause flu like symptoms?
dacarbazine and temozolomide
Which drug causes ototoxicity?
cisplatin
Which drug causes hand and foot syndrome?
5FU
Which drugs cause low myelosupression?
- cisplatin
- vincristine
- bleomycin
which drug causes pancytopenia?
dactinomycin
which drug causes leukocyte activation syndrome?
retinoic acid
Which drug causes tumor lysis and PML?
rituximab
Which drugs increase the risk of a secondary melanoma?
vemurafenib and dabrafenib
which drugs affect fertility?
- methotrexate
- alkylating agents
- trametinib and dabrafenib
Which drugs are prodrugs?
- Triazenes: dacarbazine, procarbazine, temozolomide
- mechlorethamine, cyclophosphamide, ifosphamide
- dacarbazine and temozolomide
- 5FU, cytarabine, gemcitabine
- 6MP
