Toxicities Flashcards

1
Q

Which drugs increase the risk of Leukemia

A

alkylating agents

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2
Q

Which drugs cause hepatotoxicity?

A
  • methotrexate
  • 6 MP
  • Nitolinib
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3
Q

Which drugs cause pulmonary fibrosis?

A
  • carmustine and lomustine
  • bleomycin
  • dasatinib (pulmonary hypertension)
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4
Q

Which drugs cause nephrotoxicity?

A
  • Cisplatin
  • Methotrexate
  • carmustine and lomustine
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5
Q

Which drugs cause neuropathies?

A
  • cisplatin
  • oxaliplatin (cold induced)
  • taxanes
  • vincristine
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6
Q

Which drugs cause cardiotoxicity?

A
  • anthracyclines
  • 5FU
  • Vefuramenib and Nilotinib (QT prolongation)
  • Trastuzumab (ventricular dysfunction)
  • cetuximab
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7
Q

Which drugs cause hemorrhagic cysts?

A

cyclophosphamide and ifosphamide

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8
Q

Which drug causes thrombocytopenia?

A

carboplatin

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9
Q

Which drugs cause flu like symptoms?

A

dacarbazine and temozolomide

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10
Q

Which drug causes ototoxicity?

A

cisplatin

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11
Q

Which drug causes hand and foot syndrome?

A

5FU

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12
Q

Which drugs cause low myelosupression?

A
  • cisplatin
  • vincristine
  • bleomycin
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13
Q

which drug causes pancytopenia?

A

dactinomycin

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14
Q

which drug causes leukocyte activation syndrome?

A

retinoic acid

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15
Q

Which drug causes tumor lysis and PML?

A

rituximab

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16
Q

Which drugs increase the risk of a secondary melanoma?

A

vemurafenib and dabrafenib

17
Q

which drugs affect fertility?

A
  • methotrexate
  • alkylating agents
  • trametinib and dabrafenib
18
Q

Which drugs are prodrugs?

A
  • Triazenes: dacarbazine, procarbazine, temozolomide
  • mechlorethamine, cyclophosphamide, ifosphamide
  • dacarbazine and temozolomide
  • 5FU, cytarabine, gemcitabine
  • 6MP