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Unit 1: Pharm > CYP Enzymes > Flashcards

CYP Enzymes Flashcards

1
Q

Two results seen when CYP is induced?

A

Increased active drug (for prodrugs) or increased elimination (of already active drugs)

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2
Q

Two results seen when CYP is inhibited?

A

Increased bioavailability of a drug (of an already active drug) or decreased transformation of prodrug to active drug

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3
Q

Name 2 drugs metabolized by 1A2:

A

Caffeine

Theophyillin

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4
Q

What is an inhibitor of 1A2?

A

Grapefruit juice

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5
Q

What is an inducer of 1A2?

A

Smoking

Charred food

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6
Q

What is metabolized by 2C9?

A

Phenytoin

Warfarin

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7
Q

What in an inhibitor of 2C9?

A

Macrolides

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8
Q

What is an inducer of 2C9?

A

Rifampin

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9
Q

What drugs are metabolized by 2C19?

A

Diazapem

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10
Q

What is an inducer of 2C19?

A

St. John’s wart

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11
Q

What is an inhibitor of 2C19?

A

Fluoxetine

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12
Q

What drug is metabolized by 2C6?

A

Codeine

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13
Q

What is an inhibitor of 2C6?

A

Quinidine

Haloperidol

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14
Q

What is an inducer of 2C6?

A

Rifampin

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15
Q

What drug is metabolized by 2E1?

A

Paracetanol

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16
Q

What drug is metabolized by 3A4?

A

Terfenadine

Verapamil

17
Q

What is an inhibitor if 3A4?

A

Itracenazole

Ketoconazole

18
Q

What is an inducer of 3A4?

A

St. John’s wart

19
Q

Which CYP’s are polymorphisms seen in?

A

2C9
2C19
2C6

20
Q

What type of metabolizing do people with 2C9/19 polymorphisms undergo?

A

Poor metabolizing (most common in AA’s and Asians)

21
Q

What type of metabolizing do people with 2C6 polymorphisms undergo?

A

Poor– most common in AA’s and whites

Extensive (ultra)– most common in ethiopians and southern europeans

Unit 1: Pharm (8 decks)

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