Toxicities Flashcards
Tox: Acetaminophen
Rx: N-acetylcysteine (replenishes glutathione)
Tox: Salicylates
Rx: NaHCO3 (alkalinize urine), dialysis
Tox: Amphetamines (basic)
Rx: NH4Cl (acidify urine)
Tox: AchE inhibitors, organophosphates
Rx: Atropine, Pralidoxime
Tox: Antimuscarinic, anticholinergic agents
Rx: Physostigmine salicylate, control hyperthermia
Tox: B-blockers-Bradycardia, Hypotension, CV collapse
Rx: Glucagon (incr cAMP in cardiac myocytes)
Tox: Digitalis
Rx: Normalize K+, Lidocaine, Anti-dig Fab fragments, Mg2+
Tox: Iron
Rx: Deferoxamine, deferasirox
Tox: Lead
Rx: CaEDTA, dimercaprol, succimer, penicillamine
tox: Mercury, arsenic, gold
Rx: Dimercaprol (BAL), succimer
Tox: Copper, arsenic, gold
Rx: Penicillamine
Tox: Cyanide
Rx: Nitrite + thiosulfate, hydroxocobalamin
Tox: Methemoglobin
Rx: Methylene blue, vit C
Tox: CO
Rx: 100% O2, Hyperbaric O2
Tox: Methanol, ethylene glycol (antifreeze)
Rx: Fomepizole> ethanol, dialysis
Tox: Opiods-Severe sedation, respiratory depression, miosis
Rx: Naloxone/naltrexonemu antagonists
Tox: Benzodiazepines
Rx: Flumazenil
Tox: TCAs
Rx: NaHCO3 (plasma alkalinization)
Tox: Heparin
Rx: Protamine
Tox: Warfarin
Rx: Vit K, FFP
Tox: tPA, Streptokinase, Urokinase
Rx: Aminocaproic acid
Tox: Theophylline
Rx: B-blocker for the induced cardiac arrhythmia-give Benzodiazepine and barbiturates for induced Seizures.
Rxn: Coronary vasospasm
Rx: Cocaine, sumatriptan, ergot alkaloids
Rxn: Cutaneous flushing
Rx: Vancomycin, Adenosine, Niacine, Ca2+ channel blockers, Caspofungin (by histamine release)
VANCC
Rxn: Dilated cardiomyopathy
Rx: Doxorubicin (Adriamycin), daunorubicin
Rxn: Torsades de pointes
Rx: Class III (Sotalol) and class IA (quinidine) anti-arrhyth*not Amiodarone, macrolides, antipsychotics, TCAs
Rxn: Agranulocytosis
Rx: Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone
Agranulocytosis Could Certainly Cause Pretty Major Damage
Rxn: Aplastic anemia
Rx: Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole, carbamazepine
Can’t Make New Blood Cells Properly
Rxn: Direct Coombs + hemolytic anemia
Rx: Methyldopa, PCN
Rxn: Gray baby syndrome
Rx: Chloramphenicol