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Psych Flashcards

1
Q

Trifluoperazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic4 hr dystonia, 4 day akathisa, 4 week bradykinesia, 4 mo. tardive dyskinesiaTRI to FLy High - high potency

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2
Q

Fluphenazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic4 hr dystonia, 4 day akathisa, 4 week bradykinesia, 4 mo. tardive dyskinesiaTRI to FLy High - high potency

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3
Q

Haloperidol

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency. Most likely to cause NMS: (FEVER: Fever, Enecphalopathy, Vitals unstable, Enzyme elevation, Rigid muscles) and Tardive dyskinesia4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychoticTRI to FLy High - high potency

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4
Q

Chlorpromazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Corneal deposits, Neuroloeptic malignant syndromey4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychoticTHe CLOR ~ floor (is low, potency)

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5
Q

Thioridazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), ReTinal deposits, Neuroloeptic malignant syndromey4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychoticTHe CLOR ~ floor (is low, potency)

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6
Q

Olanzapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Olanzapine specific: weight gainIt’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

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7
Q

Clozapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s2) Class/MOA: Atypical antipsychotic. Inhibits D4 receptors3) Agranulocytosis and seizures, weight gain4) Fun Facts: Must monitor WBC. Must watch clozapine’s CBZ clozelyIt’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

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8
Q

Ziprasidone

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors3) Ziprasidone prolongs QT interval. Zipirasidone puts your heart to zzzzzzzzzIt’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

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9
Q

Quetiapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.It’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

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10
Q

Risperadone

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors. ANTI-DOPAMINE –> HYPERPROLACTINEMIA3) Side effects/ADEs: Atypical most likely to cause Tardive DyskinesiaIt’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

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11
Q

Aripiprazole

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.It’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

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12
Q

Lithium

A

1) Use: Bipolar disorder, SIADH
2) Class/MOA: Not established. Inhibition of phosphoinositol cascade
3) Side effects/ADEs: Movement (tremor), Nephrogenic DI, hypOthyroidism, Pregnancy/ebstein abnormality (LMNOP), also sedation, edema, heart block.

Ebstein anomaly: apical displacement of tricuspid leaflets, decreased RV volume, atrialization of RV.

4) excreted by kidneys but most reabsorbed at the PCT after Na+. Give a diuretic or renal ds? Na+ reabsorption upregulated at the PCT? then more lithium will be reabsorbed –> toxicity

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13
Q

Buspirone

A

1) Use: Generalized anziety disorder (incr NE, Decr Serotonin and GABA)
2) Class/MOA: Stimulates 5-HT1A receptor.
3) Side effects/ADEs: No sedation, addiction or tolerance
4) Fun Facts: No interactions with barbituates or benzodiazepines. Takes 1-2 weeks to have an effect”pt starts medication, 1 week later complains that he hasn’t noticed any difference. tell pt to wait and see”“I’m always anxious if the bus will be on time, so I take BUS-pir-ONe

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14
Q

Fluoxetine

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias2) Class/MOA: SSRI3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAOi, TCAs, Linezolid, Tramadol)4) Fun Facts: Takes 4-8 weeks to have an effectFLashbacks PARalyze SEnior CITizensSexy-time Sucks w Rx Injxn

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15
Q

Paroxetine

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias2) Class/MOA: SSRI3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAOis, TCAs, Tramadol, Linezolid)4) Fun Facts: Takes 4-8 weeks to have an effectFLashbacks PARalyze SEnior CITizensSexy-time Sucks w Rx Injxn

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16
Q

Sertraline

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias2) Class/MOA: SSRI3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAOis, TCAs, Linezolid, Tramadol)4) Fun Facts: Takes 4-8 weeks to have an effectFLashbacks PARalyze SEnior CITizensSexy-time Sucks w Rx Injxn

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17
Q

Citalopram

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias2) Class/MOA: SSRI3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAOis, TCAs, Tramadol, Linezolid)4) Fun Facts: Takes 4-8 weeks to have an effectFLashbacks PARalyze SEnior CITizensSexy-time Sucks w Rx Injxn

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18
Q

Venlafaxine

A

1) Depression. Venlafaxine also in generalized anxiety, panic disorders.**
2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake
3) Increased BP, sedation, nausea

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19
Q

Duloxetine

A

1) Depression, diabetic peripheral neuropathy**. 2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake (greater effect on NE than other SNRI-venlafaxine). 3) Increased BP, sedation, nausea

20
Q

Amitriptyline

A

1) Use: Major depression, fibromyalgia
2) Class/MOA: 3rd generation tricyclic antidepression. Block reuptake ofNE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT, treat with NaBicarb)
4) Fun Facts: Third generation TCAs have more anticholinergic side effects (than nortriptyline)

21
Q

Nortriptyline

A

1) Use: Major depression, fibromyalgia
2) Class/MOA: 2nd generation tricyclic antidepression. Block reuptake NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT treat with NaBicarb)
4) Fun Facts: Second generation TCAs have fewer anticholinergic side effects (than amitriptyline)

22
Q

Imipramine

A

1) Use: Major depression, fibromyalgia, BEDWETTING
2) Class/MOA: Tricyclic antidepression. Block reuptake of NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT treat with NaBicarb)
4) Fun Facts: use for bedwetting is imipramine specific.

23
Q

Desipramine

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block reuptake of NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT treat with NaBicarb)
4) Fun Facts: Less sedating, LOWER SEIZURE THRESHOLD

24
Q

Clomipramine

A

1) Use: Major depression, fibromyalgia. First line OCD***
2) Class/MOA: Ttricyclic antidepression. Block reuptake of NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT/arrhythmia treat with NaBicarb)

25
Q

Doxepin

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block reuptake NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT-arrhythmia treat with NaBicarb)

26
Q

Amoxapine

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block reuptake of NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (arrhythmias - treat with NaBicarb)

27
Q

Tranylcypromine

A

1) Use: Atypical depression, anxiety, hypochondriasis2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)No wine and cheese in Shanghai! They drink rice sake and rice

28
Q

Phenelzine

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint) No wine and cheese in Shanghai! They drink rice sake and rice

29
Q

Isocarboxazid

A

1) Use: Atypical depression, anxiety, hypochondriasis2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)No wine and cheese in Shanghai! They drink rice sake and rice

30
Q

Selegiline

A

1) Use: Atypical depression, anxiety, hypochondriasis2) Class/MOA: Selective MAO-B inhibitor***. Increases levels of Ne, serotonin and dopamine (all amine NTs) - esp DOPAMINE3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)No wine and cheese in Shanghai! They drink rice sake and rice

31
Q

Bupropion

A

1) Use: Smoking cessation. Depression2) Class/MOA: Atypical antidepressant. Increase NE/dopamine via unknown mechanism3) Side effects/ADEs: Toxicity: tachycardia, insomnia, headache, seizures in bulimics (things that happen after sex: Insomnia-stay up all night!, HA - came too hard, Seizures - what it looks like when you’re coming, Tachycardia - damn girl that made my heart race)4) Fun Facts: No sexual side effects; B for BONER aPROPriateHelps you stop smoking so you’re sexier, grroowwlAtypical antidepressants: Bup, Mirt, Map, Traz

32
Q

Mirtazapine

A

1) Use: Depression.2) Class/MOA: Atypical antidepressant. Alpha2 antagonist (increases NE and serotonin), potent 5-HT2 and 5-HT3 receptor antagonist3) Side effects/ADEs: Toxicity: sedation, increase in appetite, weight gain, dry mouth4) Fun Facts: May be used in anorexics due to side effect of weight gain (tricky)Sedation (good for insomniac pts!), weight gain (good for anorexics!) dry mouth (good for anorexics who have parotid gland excessive secretion)Atypical antidepressants: Bup, Mirt, Map, Traz

33
Q

Trazodone

A

1) Use: Depression (at high doses). INSOMNIA2) Atypical antidepressants: inhibits serotonin reuptake3) Side effects/ADEs: Sedation (makes you really fucking sleepy!), nausea, priapism, postural hypotension (so you want to lie down!)4) Fun Facts: Called trazoBONE bc it gives you a huge one when you wake up in the morning after your first sleep in a long timeAtypical antidepressants: Bup, Mirt, Map, Traz

34
Q

Serotonin Syndrome sxs

A

-Neuromuscular excitation: Hyperreflexia, clonus, mycolonus, rigidity-Autonomic stimulation: tachycardia, diaphoresis, tremor, hyperthermia, flushing-Atlered mental status: agitation, seizures, confusionAntidote: Cryoheptadine (5-HT2 antagonist)

35
Q

Methylphenidate (Ritalin)

A

1) ADHD, narcolepsy, appetite control

2) Incr catecholamines at the synaptic cleft, esp NE and Dopamine

36
Q

Dextroamphetamine (Adderall)

A

1) ADHD, narcolepsy, appetite control2) Incr catecholamines at the synaptic cleft, esp NE and Dopamine

37
Q

methamphetamine

A

1) ADHD, narcolepsy, appetite control2) Incr catecholamines at the synaptic cleft, esp NE and Dopamine

38
Q

Tx for bulimia

A

SSRIs

39
Q

Tx for OCD

A

SSRIs, clomipramine (TCA)

40
Q

Tx for Panic disorder

A

SSRIs, venlafaxine (SNRI), benzos

41
Q

Tx for PTSD

A

SSRIs

42
Q

Tx for social phobias

A

SSRIs, beta blockers

43
Q

SSRI mnemonic

A

Flashbacks Paralyze Senior Citizens

Fluoxetine, Paroxetine, Sertraline, Citalopram

44
Q

Tx for Serotonin syndrome

A

Cyproheptadine (5-HT2 receptor antagonist)

45
Q

MAOI mnemonic

A

MAO Takes Pride In Shanghai

Tranylcypromine, Phenelzine, Isocarboxazid, Seligiline (selective MAO-B inhibitor)

Pharm (15 decks)

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