toxic metals Flashcards

1
Q

three ways to classify metals

A

major toxic metals, essential metals, metals and medicine

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2
Q

three ways to classify metals: major toxic metals

A

Not necessary to sustain life
Toxic at both acute and chronic exposure levels
Arsenic (semimetal), beryllium, cadmium, chromium, lead, mercury, nickel

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3
Q

three ways to classify metals: essential metals

A

Essential for life at trace amounts, but have the potential for toxicity at high concentrations
Iron, copper, magnesium, zinc

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4
Q

three ways to classify metals: metals and medicine

A

Metals used for medical therapy

Aluminum, lithium, platinum

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5
Q

five main routs of exposure to heavy metals

A

air, soil, dust, water, biota

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6
Q

Arsenic (As)

A

What is it: Crystalline metalloid

How are we exposed: Naturally occurs
Once used for medical purposes
industrial/commercial sources

How common is exposure?: ubiquitous in soil and water
2001 EPA standard for As in drinking water

How does it affect us: Acutely poisonous, varies in toxicity depending on chemical form
Risk factor for cancer
Melanosis
Adverse pregnancy outcomes

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7
Q

Beryllium

A

What is it: light, yet strong metal, commonly used for industrial purposes

How are we exposed: inhalation

How common is exposure?: highest levels in occupational settings
Coal burning emissions

How does it affect us: Berylliosis → chronic beryllium disease (CBD)
Influenced by genetic susceptibility
Carcinogenic

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8
Q

Cadmium

A

What is it: found in soils, rocks and coal

How are we exposed:
Dietary intake → bioaccumulation in shellfish and plants
Occupation (mining and battery production)

How common is exposure?: highest levels in occupational settings but common exposure through cigarettes and diet

How does it affect us:
High blood pressure → cardiovascular disease
Kidney damage
Itai-itai disease

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9
Q

Chromium

A
What is it: naturally occurs in soils and volcanic minerals
Various forms (essential and toxic)

How are we exposed:
Occupational → inhalation
General → dietary

How common is exposure?: contaminated food and water

How does it affect us:
Carcinogen, organ damage, digestive issues, skin ulcers and respiratory problems

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10
Q

mercury

A

What is it: naturally occurring, exists in three forms (quicksilver)

How are we exposed:
Once used as a medicine
Ingestion: dental amalgams, diet bioaccumulation
Inhalation: occupational (cinnabar processing)

How common is exposure?: depends on diet

How does it affect us:
Fetal and child brain development
Neurologic outcomes → minamata disease

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11
Q

Nickel

A

What is it: found in earth’s crust

How are we exposed: through low levels from industrial products
Occupational: inhalation and dermal

How common is exposure?: universal and unavoidable

How does it affect us:
Skin allergy
Cardiovascular disease
Fibrosis of the lungs → respiratory cancers

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12
Q

example of ways heavy metals are in the air

A

Mainly occupational

Smelting, mining

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13
Q

example of ways heavy metals are in the soil

A

mining/smelting
Ingestion: mainly toddlers and babies
Lead → paint chips

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14
Q

example of ways heavy metals are in the dust

A

mining/smelting
Ingestion: mainly toddlers and babies
Lead → paint chips

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15
Q

example of ways heavy metals are in the water

A
Naturally occurs
Well water vs. public water
Arsenic / mercury 
Rust from pipes (iron)
Old pipes (lead)
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16
Q

example of ways heavy metals are in the biota

A
biomagnification/bioaccumulation
(mercury in fish)
Organotin pesticides
(End up in water → fish)
Leaded glaze and glass
(Paprika and wheat)
17
Q

Biomagnification/bioaccumulation

A

The gradual buildup of substances, such as pesticides, or other chemicals in an organism