toxic metals Flashcards
three ways to classify metals
major toxic metals, essential metals, metals and medicine
three ways to classify metals: major toxic metals
Not necessary to sustain life
Toxic at both acute and chronic exposure levels
Arsenic (semimetal), beryllium, cadmium, chromium, lead, mercury, nickel
three ways to classify metals: essential metals
Essential for life at trace amounts, but have the potential for toxicity at high concentrations
Iron, copper, magnesium, zinc
three ways to classify metals: metals and medicine
Metals used for medical therapy
Aluminum, lithium, platinum
five main routs of exposure to heavy metals
air, soil, dust, water, biota
Arsenic (As)
What is it: Crystalline metalloid
How are we exposed: Naturally occurs
Once used for medical purposes
industrial/commercial sources
How common is exposure?: ubiquitous in soil and water
2001 EPA standard for As in drinking water
How does it affect us: Acutely poisonous, varies in toxicity depending on chemical form
Risk factor for cancer
Melanosis
Adverse pregnancy outcomes
Beryllium
What is it: light, yet strong metal, commonly used for industrial purposes
How are we exposed: inhalation
How common is exposure?: highest levels in occupational settings
Coal burning emissions
How does it affect us: Berylliosis → chronic beryllium disease (CBD)
Influenced by genetic susceptibility
Carcinogenic
Cadmium
What is it: found in soils, rocks and coal
How are we exposed:
Dietary intake → bioaccumulation in shellfish and plants
Occupation (mining and battery production)
How common is exposure?: highest levels in occupational settings but common exposure through cigarettes and diet
How does it affect us:
High blood pressure → cardiovascular disease
Kidney damage
Itai-itai disease
Chromium
What is it: naturally occurs in soils and volcanic minerals Various forms (essential and toxic)
How are we exposed:
Occupational → inhalation
General → dietary
How common is exposure?: contaminated food and water
How does it affect us:
Carcinogen, organ damage, digestive issues, skin ulcers and respiratory problems
mercury
What is it: naturally occurring, exists in three forms (quicksilver)
How are we exposed:
Once used as a medicine
Ingestion: dental amalgams, diet bioaccumulation
Inhalation: occupational (cinnabar processing)
How common is exposure?: depends on diet
How does it affect us:
Fetal and child brain development
Neurologic outcomes → minamata disease
Nickel
What is it: found in earth’s crust
How are we exposed: through low levels from industrial products
Occupational: inhalation and dermal
How common is exposure?: universal and unavoidable
How does it affect us:
Skin allergy
Cardiovascular disease
Fibrosis of the lungs → respiratory cancers
example of ways heavy metals are in the air
Mainly occupational
Smelting, mining
example of ways heavy metals are in the soil
mining/smelting
Ingestion: mainly toddlers and babies
Lead → paint chips
example of ways heavy metals are in the dust
mining/smelting
Ingestion: mainly toddlers and babies
Lead → paint chips
example of ways heavy metals are in the water
Naturally occurs Well water vs. public water Arsenic / mercury Rust from pipes (iron) Old pipes (lead)