Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SU-18 ER > Tox 2 > Flashcards

Tox 2 Flashcards

You may prefer our related Brainscape-certified flashcards:
Royal College: Emergency Medicine flashcards
1
Q

CCB symptoms

A

vasodilation and HoTN***

decreased perfusion = CNS and pulmonary manifestations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

severe CCB OD sxs

A

complete heart block
depressed myocardial contractility
vasodilation = CV collapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

non DHP OD

A

sinus Brady
av block
HoTN

I.e. verapamil, diltizem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

DHP OD

A

TACHYCARDIA
peripheral vasodilation
HoTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

pulm manifestations CCB toxicity

A

due to decreased perfusion

can be seen if given execss crystalloid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CNS symptoms CCB toxicity

A

seizure
delirium
coma

secondary to hypo perfusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

EKG findings CCB toxicity

A

sinus bradycardia

AV block

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

lab findings CCB toxicity

A

hyperglycemia

lactic acidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CI of oral activated charcoal

A

> 2 hrs

AMS, vomiting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

list of pharm tx CCB toxicity

A
  1. atropine
  2. Ca salts
  3. IV crystalloid
  4. pressers
  5. cardiac pacing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

IV cyrstalloid CCB toxicity

A

HoTN management

over resuscitation = produce or worsen pulmonary edema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

pacing CCB toxicity

A

indicated if HoTN and severe Brady (< 30 bpm)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

digoxin tx for?

A

AF and symptomatic CHF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

digoxin MOA

A

inhibitor of Na-K ATPase

toxicity = increased intracellular Na, Ca, extracellular K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

digoxin Ca accumulation

A

augments inotrophy

results in PVC and dysrhythmia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

digoxin cardiac glycoside

A

increased vagal tone = reduction in conduction thru SA and AV nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

manifestations of gen digoxin toxicity

A

Syncope, dysrhythmia
GI distress, dizzy, HA, weak, confusion/AMS

**Bradycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

acute digoxin toxicity sxs

A

neuro manifestations

yellow green halo in vision (xanthopsia)

hyperkalemia***

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

chronic digoxin toxicity sxs

A

renal function/decreased body mass

GI symptoms

Neuro (weakness, fatigue, confusion, delirium)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

how is digoxin toxicity diagnosed?

A

EKG

T wave flattening/inversion
scooped ST segment

dig level increase = 6 hrs after ingestion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

antidote of digoxin toxicity

A

Dig-Fab/Digibind

binds to digoxin in plasma, removes from tissues

given if HyperK presents

22
Q

Lithium toxicity with what drug?

A

TZDs

also in renal insufficiency

succinylcholine and vecuronium prolonged effect

23
Q

ADR of Lithium toxicity

A 
fine postural hand tremor 
fatigue 
polyuria (loss of ability to concentrate urine) 
hypothyroid 
development of ataxia/dysarthria
24
Q

Lithium toxicity tx

A

hemodialysis
IVF
ABCD

25
Q

hemodialysis indications Lithium toxicity

A

impaired renal function
seizure activity
dysrhythmia
lithium level >4.0 mEq

26
Q

Carbon Monoxide

Patho

A

Colorless, odorless gas

Combines with HgB to form COHgB which has greater affinity for O2 than tissues

Decreased oxygen delivery to tissue

27
Q

Carbon Monoxide

Sources of Exposure

A

Smoke, car exhaust, hibachi grill, kerosene heater, methylene chloride

28
Q

CO S/S based on saturation

<5%

A

none/mild HA

29
Q

CO S/S based on saturation

10%

A

Slight HA, dyspnea on vigorous exercise

30
Q

CO S/S based on saturation 20%

A

Throbbing HA, dyspnea with moderate exertion

31
Q

CO S/S based on saturation 30%

A

Severe HA, irritability, fatigue, dim vision

32
Q

CO S/S based on saturation 40-50%

A

tachycardia , confusion, lethargy, syncope,

33
Q

CO S/S based on saturation 50-70%

A

Coma, death

34
Q

CO S/S based on saturation >70%

A

Rapidly fatal

35
Q

CO poison key Clinical features

A

Tachycardia, pallor skin (early), cherry red skin (late)

36
Q

CO

Tx

A

Humidified oxygen

+/- HBO

37
Q

Salicylate Toxicity

Clinical Features

A

Agitation, altered, diaphoretic, tinnitus, n/v, tachycardia and hyperventilation, fever

38
Q

Salicylate Toxicity

Toxic Effects

A
  1. Central respiratory stimulation (respiratory alkalosis and secondary metabolic acidosis)
  2. Uncoupling of oxidative phosphorylation
  3. Interference with lipid and carbohydrate metabolism
  4. Acid Base abnormalities
  5. Decreased PCO2 and respiratory alkalosis
  6. Anion gap metabolic acidosis (lactic acidosis and ketoacidosis
39
Q

Salicylate Toxicity labs

A 
BMP (anion gap) 
ABG
Glucose 
Cr 
Salicylate normal (NML 15-30)
40
Q

Salicylate Toxicity tx

A

Activated charcoal
Correction of fluid and electrolytes
IV sodium bicarbonate
Hemodialysis

Intubation is dangerous in these patients (removes ability to compensate for acidosis)

41
Q

acute Salicylate Toxicity

A

Single ingestion >300 mg/kg

Hemodialysis: >100 mg/dL

42
Q

chronic Salicylate Toxicity

A

Non specific symptoms (confusion, dehydration and metabolic acidosis)

Hemodialysis: >60 mg/dL

43
Q

Isopropranolol Clinical Features

A

CNS depression
Hemorrhagic gastritis
Pulmonary edema, hypoglycemia
Severe HoTN

44
Q

IsopropranololTx

A

ABCs
IV hydration
Hemodialysis

45
Q

Methanol source

A

Windshield fluid, antifreeze, moonshine

46
Q

Methanol Symptoms

A

12-18 hrs later

Visual change/blurring 
Scotomata 
Snow storm blindness
Seizure 
Respiratory failure
47
Q

Ethylene Glycol

Clinical Features

A

Flank pain
Hematuria
Oliguria seizure
Respiratory failure

48
Q

tx

Methanol and Ethylene Glycol

A

Supportive
4-MP fomepizole
IV ETOH
Sodium bicarbonate and hemodialysis

49
Q

Anion Gap Metabolic Acidosis

A

Na - (Cl + HCO3)

NML: 8-12 mEq/L
If elevated, MUDPILES

50
Q

MUDPILES

A

etiologies of anion gap metabolic acidosis

M methanol 
U  uremia
D DKA
P paraldehyde 
I INH, Iron, Isopropyl alcohol 
L Lactic Acidosis 
E ethylene glycol 
S salicylates
51
Q

Osmol Gap

A

Used to evaluate unexplained anion gap

MC 2/2: methanol, ethylene glycol, isopropanol

SU-18 ER (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions