Tox

Question 1

Identify the routes for toxin exposure and factors influencing absorption including dose.

Answer 1

Inhalation, ingestion, skin
higher dose = faster effects and faster absorption

Question 2

Distinguish between acute and chronic toxicity.

Answer 2

Acute: short term expose to enough toxin to cause immediate effects
Chronic: Long term exposure to lower doses that bioaccumulate

Question 3

List the major toxicants discussed.

Answer 3

Alcohols
caustics
CO
cyanide
metals: arsenic, mercury, cadmium, lead
pesticides
therapeutic drugs
drugs of abuse

Question 4

Explain the pathologic mechanisms of the major toxicants.

Answer 4

Alcohols: Biotransformation in liver
caustics: aspiration and ingestion.
CO: carboxyhemoglobin.
cyanide: inhalation, ingestion, skin
metals: arsenic, mercury, cadmium, lead: environmental ingestion.
pesticides: contaminated veggies
therapeutic drugs: Over use/unprescribed use.
drugs of abuse: ingestion/inhalation.

Question 5

Select common qualitative and quantitative toxicology test methods.

Answer 5

Chromogenic
Immunoassays
heavy metal panels