Review Questions

Question 1

The major transporter of drugs

Answer 1

Albumin

Question 2

The phenomenon in which a drug is metabolized and results in a reduced concentration of the drug before reaching the circulatory system

Answer 2

First Pass Effect

Question 3

The study of the biochemical and physiological effects of drugs and their mechanisms of actions:

Answer 3

Pharmacodynamics

Question 4

This tumor marker often is measured in both the total and free form

Answer 4

PSA

Question 5

The concentration range of a drug within which the drug produces the desired effect

Answer 5

Therapeutic Range

Question 6

This tumor marker is primarily used as a marker for ovarian cancer:

Answer 6

CA-125

Question 7

This is found as a contaminant of homemade liquors and can cause optic neuropathy:

Answer 7

Methanol

Question 8

This is a significant environmental pollutant and is easily taken up by crops – especially tobacco:

Answer 8

Cadmium

Question 9

This is a cardioactive drug that is used to treat arrythmias and CHF. Biotin is known to interfere with this test:

Answer 9

Digoxin

Question 10

The most direct and effective route of administration of a drug:

Answer 10

IV

Question 11

This is a common malignant tumor in kids associated with high levels of plasma, epinephrine, norepinephrine and dopamine:

Answer 11

Neuroblastoma

Question 12

This test is used along with hCG to classify nonseminomatous tumor

Answer 12

AFP

Question 13

This is a kind of testing method that can be performed on solid tissue tumor markers:

Answer 13

Immunohistochemistry

Question 14

The predicted dose that would produce a toxic response in 50% of the population:

Answer 14

TD50

Question 15

This may occur when analyte concentrations exceed the analytical range excessively

Answer 15

Hook Effect

Question 16

This drug is the hepatic metabolite of procainamide

Answer 16

NAPA

Question 17

The study of the movement of drugs in the body:

Answer 17

Pharmacokinetics

Question 18

This drug commonly is tested for both the total and free forms:

Answer 18

Phenytoin (Dilantin)

Question 19

Endogenous substances biologically synthesized either in living cells or in microorganisms:

Answer 19

Toxins

Question 20

This method of analysis of toxic agent has good sensitivity but lacks specificity:

Answer 20

Screening

Question 21

These types of tumor markers are valuable in diagnosing neuroblastomas, pituitary and adrenal adenomas:

Answer 21

Endocrine Tumor Markers

Question 22

This tumor marker is the prototypical oncofetal antigen and is used for monitoring colorectal cancer:

Answer 22

CEA

Question 23

Uses the results from animal experiments to predict what level of exposure will cause harm to humans:

Answer 23

Descriptive Toxicology

Question 24

This is a metal with 3 forms, one of which is liquid at room temp:

Answer 24

Mercury

Question 25

This is a useful system to compare relative toxicities of substances as the predicted endpoint is death:

Answer 25

Dose-Response Relationship

Question 26

B-macroglobulin and immunoglobulins are part of this group of tumor markers

Answer 26

Serum Protein Tumor Markers

Question 27

Chemicals and drugs that are not normally found in or produced by the body:

Answer 27

Xenobiotics

Question 28

“Trace Element Free”

Answer 28

Royal Blue Top Tube

Question 29

This is an example of something that can have significant interference in immunoassays by cross-linking with the capture/label antibody:

Answer 29

HAMAs

Question 30

This drug is ototoxic enough that it is recommended that baseline audiology testing is performed:

Answer 30

Tobramycin

Question 31

This type of tumor marker can help to choose between endocrine and cytotoxic therapies:

Answer 31

Receptor Tumor Marker