Tox Flashcards
Isoniazid (INH) toxicity presents with:
- Seizures refractory to conventional therapy
- Severe acidosis
- Coma
Treatment for isoniazid (INH) toxicity:
Pyridoxine (vitamin B6)
Death cap (Amanita phalloides) mushroom poisoning treatment:
IV N-acetylcysteine (NAC)
Hypermagnesemia treatment in pt with normal renal function:
Crystalloid infusion.
Treatment for serotonin syndrome
BZDs, cyproheptadine, removing the offending agent
Toxic alcohol ingestions that produce early HAGMA
Methanol and ethylene glycol
Toxic alcohol ingestions that do NOT produce early HAGMA
isopropyl alcohol
Treatment for methanol or ethylene glycol ingestion
Fomepizole
What are the two classic dysrhythmias associated with digoxin toxicity?
Bidirectional ventricular tachycardia and atrial dysrhythmias with AV block such as slow atrial fibrillation.
What recreational drug can cause: euphoria, agitation, hyperthermia, dehydration, rhabdomyolysis, and elevated creatinine, hyponatremia, hepatotoxicity, renal failure, and disseminated intravascular coagulation
MDMA, Ecstacy
What drug tox can cause: Respiratory alkalosis + anion gap metabolic acidosis, hypoglycemia, tinnitus?
Salicylic acid
Acute medication toxicity that presents with: Nausea/vomiting, urine concentrating defects, neurologic (weakness to twitching to coma), prolonged QT, ST/T wave changes, hypothyroidism, and leukocytosis.
Lithium
Treatment for acute lithium tox
HD if:
- Impaired kidney function and > 4.0 concentration
- Lithium > 5.0
- seizure, dangerous dysrhythmia, AMS
- contraindication to aggressive hydration (heart failure)
Methanol tox symptoms:
CNS depression, visual disturbances (“snowstorm”), abdominal pain, nausea and vomiting.
Gamma hydroxybutyrate (GHB) intoxication presentation:
Decreased LOC, euphoria, nystagmus, dizziness, respiratory depression with apnea, interrupted by periods of agitation and combativeness.
