Total Body Irradiation And Early/Late Effects Flashcards
How long does the prodromal stage last?
The prodromal stage may last a few minutes to days.
What are the symptoms of the prodromal stage?
Symptoms include nausea, vomiting, and diarrhea.
What happens in the latent stage?
The person usually appears healthy
Changes are taking place in systems damaged by radiation
What is the duration of the Manifest Stage?
May last a few minutes to weeks
What are the possible outcomes for an individual in the Manifest Stage?
Individual either recovers or dies
What is mean survival time in radiation syndromes?
Time between radiation exposure and death.
What does LD 50/30 represent?
Lethal dose to 50% of population in 30 days.
Which is more relevant for humans, LD 50/30 or LD 50/60?
LD 50/60 is more relevant in humans.
What is the LD 50/60 for humans?
2.5-3.0 Gy.
What are the symptoms of the Prodromal stage?
Symptoms include nausea, vomiting, diarrhea, fatigue, and leukopenia.
What occurs during the Latent stage?
There are no symptoms during the Latent stage.
What are the symptoms of the Hematopoietic stage?
Symptoms include nausea, vomiting, diarrhea, decrease in red blood cells, white blood cells, and platelets; hemorrhage; and infection.
What is the survival time for the Hematopoietic stage?
Survival time is 6 to 8 weeks for doses over 2 Gy.
What are the symptoms of the Gastrointestinal stage?
Symptoms include severe nausea, vomiting, diarrhea, fever, fatigue, loss of appetite, lethargy, anemia, leukopenia, hemorrhage, infection, electrolytic imbalance, and emaciation.
What is the survival time for the Gastrointestinal stage?
Survival time is 3 to 10 days.
What are the symptoms of the Cerebrovascular stage?
Symptoms include those of hematopoietic and gastrointestinal stages, plus excessive nervousness, confusion, lack of coordination, loss of vision, burning sensation of the skin, loss of consciousness, disorientation, shock, agitation alternating with stupor, edema, loss of equilibrium, meningitis, prostration, respiratory distress, vasculitis, and coma.
What is the survival time for the Cerebrovascular stage?
Survival time ranges from several hours to 3 days.
What dose does acute hematopoietic radiation syndrome occur?
1-10 Gy
What dose does acute gastrointestinal radiation syndrome occur?
6-10 Gy
What dose does acute cerebrovascular radiation syndrome occur?
50 Gy and above
What is the estimated 50/30 for humans?
3-4 Gy
What is the effect of radiation in the first two weeks of pregnancy?
Death
What is the effects of radiation in the first trimester of pregnancy?
Congenital abnormalities
most sensitive time period
What are the effects of radiation on the 2nd and 3rd trimester of pregnancy?
No long term effects are present at birth
