Topoisomerase Inhibitors

Question 1

topoisomerase I

Answer 1

breaks and reseals single-stranded DNA

Question 2

topoisomerase II

Answer 2

breaks and reseals double-stranded DNA

Question 3

etoposide, teniposide general/MOA

Answer 3

topoisomerase inhibitors, epipodophyllotoxins
semisynthetic derivatives of podophyllotoxin
inhibit topoisomerase II, resulting in damaged DNA

Question 4

etoposide TU

Answer 4

testicular, lung, non-Hodgkins

Question 5

teniposide TU

Answer 5

mainly ALL

Question 6

etoposide, teniposide Tox

Answer 6

dose-limiting neutropenia

oral mucositis

Question 7

irinotecan, topotecan general/MOA

Answer 7

topoisomerase inhibitors, camptothecin analogs
synthetic analogs to camptothecin from Chinese plant Camptotheca acuminata
inhibit topoisomerase I, leading to ss break accumulation

Question 8

irinotecan TU

Answer 8

advanced colorectal

lung, ovarian, cervical, brain

Question 9

topotecan TU

Answer 9

ovarian, small cell lung cancer

Question 10

irinotecan, topotecan Tox

Answer 10

severe neutropenia, severe diarrhea