Topical Corticosteroids

Question 1

Corticosteroids mechanism of action

Answer 1

Inhibit phospholipase A2

Question 2

Corticosteroids therapeutic effects

Answer 2

Inhibit lymphocyte + cytokine + epidermal mitosis

Question 3

Corticosteroids adverse effects (systemic)

Answer 3

Suppress HPA axis -> Cushing

Premature epiphyseal closure

Hyperglycemia -> DM

Question 4

Corticosteroids adverse effects (local)

Answer 4

Skin atrophy (most common)

Telangiectasia (dilate cut. vessel) + purpura + striae

Hypertrichosis, hypopigmentation

Steroid acne, perioral dermatitis

Infection + tinea incognito + delayed healing

Question 5

Clobetasol propionate cream (potency?)

Answer 5

Super potent

Question 6

Betamethasone dipropionate ointment or cream (potency?)

Answer 6

High potency

Question 7

Triamcinolone acetonide (potency?)

Answer 7

Middle potency

Question 8

Hydrocortisone cream (potency?)

Answer 8

Low potency

Question 9

Prednisolone cream (potency?)

Answer 9

Low potency

Question 10

Corticosteroids contraindications

Answer 10

Drug allergy, superinfection

อย่าให้ class 1-3 กับเด็ก <12 yrs และคนแก่