Topic H Health Related Quality of Life

Question 1

3 Methods to Measure Health States

Answer 1

Utility Measures
HRQoL Measures
Preference Based Classification

Question 2

Utility Measures

Answer 2

Preference based or Choice based measures
Estimate utility by using standard gamble & time tradeoff. Time consuming and resource intensive.

Question 3

HRQoL Meaures

Answer 3

Non-Utility or Non-Preference Measures

Question 4

General/Generic Measures

Answer 4

Scores can be compared for many disease status and conditions. May not be sensitive to clinically relevant difference for every disease or condition.
SF-36
SF-12

Question 5

Disease Specific Measures

Answer 5

Condition Specific
More narrowly focused patient views, cannot compare across populations.
Physical symptoms distress index (HTN)
Living with asthma questionnaire (Asthma)

Question 6

SF-36

Answer 6

The Short Form 36 Health Survey
Short form of the Medical Outcomes Survey
Most common generic HRQoL instrument used
Also includes a self evaluation of change in health during the past year

Question 7

SF-12

Answer 7

An even shorter version of the questionnaire consisting of only 12 questions developed for practical use.

Question 8

HRQoL Tools

Answer 8

4 Dimension/Domains & 3 Instruments

Question 9

4 Dimensions/Domains

Answer 9

Physical Functioning
Psychological (Mental) Functioning
Social/ Role Functioning
General Health Perception

Question 10

3 Instruments

Answer 10

Reliability
Validity
Responsiveness

Question 11

4 Dimensions/Domains: Physical Functioning

Answer 11

Capture information on the observable limitations or disability experienced by the patient over a defined period of time.

Question 12

Physical Functioning Examples

Answer 12

Activities of daily living
Energy level
Bodily pain

Question 13

4 Dimensions/ Domains: Psychological Functioning (Mental)

Answer 13

Capture information on psychological distress that can be the consequence of a disease or a side effect of a treatment.

Question 14

Psychological (Mental) Functioning Examples

Answer 14

Anxiety, Depression, Moodiness
Life Satisfaction
Cognitive Function

Question 15

4 Dimensions/ Domains: Social/ Role Functioning

Answer 15

Social: Capture information on the ability to develop, maintain, and nurture social relationships
Role: Capture information on the patients duties and responsibilities that are limited by health condition

Question 16

4 Dimensions/ Domains: General Health Perception

Answer 16

Capture information on patients overall beliefs and evaluations about their health

Question 17

3 Instruments: Reliabilty

Answer 17

The consistency of an intstrument
1. Test-Retest
2. Internal Consistency
3. Interrater

Question 18

Reliability bs Validity

Answer 18

Together in the blue box is reliable
All together in the red inner box is valid
- A reliable test may or may not be valid
- All valid tests are reliable

Question 19

3 Instruments: Validity

Answer 19

True respresentation

Question 20

3 Instruments: Validity - Content

Answer 20

AKA Face Validity
Pertains whether the HRQoL instrument offers an adequate representation of the relevant variables of the intrest

Question 21

3 Instruments: Validity - Criterion

Answer 21

AKA Predicative Validity
The instrument scores correlate with or predict health outcomes

Question 22

3 Instruments: Validity - Construct

Answer 22

Convergent
Discriminant
Known Group

Question 23

3 Instruments: Responsiveness

Answer 23

Captures information on changes in health states