Topic Five - Regulation of Systems Flashcards

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1
Q

What is homeostasis?

A

Homeostasis is a complex process that maintains the internal environment of an organism within set limits so that cells and systems can function properly.

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2
Q

What parameters affect the functioning of cells?

A

Parameters that affect the functioning of cells include temperature, pH (acidity level), blood sugar levels, sodium and potassium concentration, and fluid balance.

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3
Q

What is the stimulus-response model?

A

The stimulus-response model outlines how changes in the external and internal environment can influence an organism’s function.

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4
Q

What are the five components of the stimulus-response model?

A

The five components are stimulus, receptor, modulator, effector, and response.

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5
Q

What is a positive feedback system?

A

A positive feedback system occurs when the response increases the initial stimulus. It is rare in the body and doesn’t form part of homeostasis.

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6
Q

What is a negative feedback system?

A

A negative feedback system occurs when the response counters the stimulus. The response attempts to revert the system back to the set point – the value the body aims to maintain a given variable at. Homeostasis typically involves negative feedback loops.

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7
Q

What is cellular signaling?

A

Cellular signaling is the process of detecting a stimulus, transmitting a signal during cellular signaling, and producing a response.

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8
Q

What are the three steps of cellular signaling?

A

The three steps of cellular signaling are reception, transduction, and response.

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9
Q

What is the purpose of homeostasis?

A

Homeostasis maintains a constant internal environment in the body so cells can continue to function despite changes to the external environment.

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10
Q

What is the concept of feedback loops?

A

The concept of feedback loops is an important part of homeostasis, where negative feedback loops attempt to counter the stimulus and maintain the internal environment within set limits.

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11
Q

cellular signalling; Reception

A

The first step in cellular signaling.
The process of detecting a signal or stimulus by a cell receptor.
The signal can be mechanical, electrical, or chemical.
After reception, the signal is transmitted to the cell’s interior.

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12
Q

cellular signalling; Transduction

A

The second step in cellular signaling.
The process of transmitting a signal from the cell membrane to the interior of the cell.
The signal can be transmitted by molecules, ions, or other mechanisms.
Transduction can involve sending a signal between organisms, across the body, to a neighboring cell, or back to the original receptor cell.

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13
Q

cellular signalling; Response

A

The third and final step in cellular signaling.
The change in the function of a target cell, organ, or organism.
The response can be activation of an enzyme, secretion of a hormone, or contraction of a muscle, among other possibilities.
The response can be immediate or delayed.

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14
Q

What are the four main ways heat transfer can occur?

A

Heat can transfer through conduction, convection, radiation, and evaporation.

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15
Q

What is the difference between endotherms and ectotherms?

A

Endotherms (warm-blooded animals) are able to generate their heat energy internally using metabolic processes, while ectotherms (cold-blooded animals) produce very little metabolic energy and rely on environmental sources of heat to warm themselves.

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16
Q

What is thermoregulation?

A

Thermoregulation is the process by which an organism regulates its internal body temperature within a certain range, in order to maintain normal biological function.

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17
Q

What is the role of the hypothalamus in thermoregulation in humans?

A

The hypothalamus is the modulator in the thermoregulation process in humans. It sends messages to a variety of effector cells and tissues throughout the body, in response to the thermoreceptor’s detection of temperature changes.

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18
Q

What is the stimulus for thermoregulation in humans?

A

The stimulus for thermoregulation in humans is a change in core body temperature or the environmental temperature.

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19
Q

How does the human body respond to changes in temperature during thermoregulation?

A

The human body responds to changes in temperature by creating a response that causes a change in heat transfer, helping to maintain a core body temperature of 37°C.

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20
Q

What is negative feedback in thermoregulation in humans?

A

Negative feedback is the process by which the body responds to temperature changes and takes corrective action to maintain a stable internal body temperature.

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21
Q

What are the different factors that help to counter changes in environmental temperature during thermoregulation in humans?

A

Factors such as sweating, shivering, vasoconstriction, and vasodilation help to counter changes in environmental temperature during thermoregulation in humans. They all aim to either increase or decrease the heat generated/lost via the heat transfer principles of conduction, convection, evaporation, and radiation.

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22
Q

Convection

A

Definition: Convection is the transfer of heat through the movement of fluids (liquids or gases).
Example: Boiling water on a stove, where heat from the burner causes the water at the bottom of the pot to become hot and rise to the top, displacing the cooler water, which then sinks to the bottom and is heated.
Key points: Convection occurs in fluids (liquids and gases), and it involves the movement of the fluid itself as a means of heat transfer.

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23
Q

Conduction

A

Definition: Conduction is the transfer of heat through direct contact between two materials of different temperatures.
Example: Touching a hot pan on a stove, where the heat from the pan is transferred to your hand through direct contact.
Key points: Conduction occurs through direct contact between two materials, and it requires a temperature difference between them to occur.

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24
Q

Evaporation

A

Definition: Evaporation is the transfer of heat through the conversion of a liquid into a gas.
Example: Sweating, where heat from your body causes sweat to evaporate, taking heat away from your skin and cooling you down.
Key points: Evaporation requires a liquid to be present, and it involves the conversion of the liquid into a gas, which takes heat away from the source.

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25
Q

Radiation

A

Definition: Radiation is the transfer of heat through the emission and absorption of electromagnetic waves.
Example: Feeling the warmth of the sun on your skin, where heat from the sun is transferred to your body through the emission of electromagnetic waves.
Key points: Radiation occurs through the emission and absorption of electromagnetic waves, and it can occur in a vacuum (whereas the other methods of heat transfer require a medium).

26
Q

Glucose

A

The main source of energy for all cells in the body, obtained from the breakdown of carbohydrates through digestion.

27
Q

Glycogen

A

A complex carbohydrate made up of glucose molecules, stored in the liver and skeletal muscles.

28
Q

Glycogenesis

A

The process by which glucose molecules are joined together to form glycogen.

29
Q

Glycogenolysis

A

The process by which glycogen is broken down into glucose.

30
Q

Islets of Langerhans

A

Clusters of specialized cells located in the pancreas that secrete insulin and glucagon.

31
Q

Insulin

A

A hormone released by beta cells in the pancreas that lowers blood glucose levels by promoting glucose uptake by cells and glycogen synthesis in the liver and muscles.

32
Q

Glucagon

A

A hormone released by alpha cells in the pancreas that raises blood glucose levels by stimulating glycogen breakdown in the liver and glucose release into the bloodstream.

33
Q

Homeostasis

A

The maintenance of stable internal conditions in the body, including blood glucose levels.

34
Q

Negative feedback

A

A feedback system that counteracts a change in a variable and brings it back to a set point, as in the case of blood glucose regulation.

35
Q

Cellular Respiration

A

The process by which cells break down glucose to produce ATP, the energy currency of the cell.

36
Q

Stimulus for Blood Glucose Regulation?

A

Change in blood glucose levels

37
Q

What is the receptor for Blood Glucose Regulation?

A

The pancreas, specifically, clusters of specialized cells called the islets of Langerhans

38
Q

What is the modulator for Blood Glucose Regulation?

A

The islets of Langerhans

39
Q

What is released in Blood Glucose Regulation and what does it depend on?

A

Insulin or glucagon is released, depending on whether glucose levels are high or low

40
Q

What is the response in Blood Glucose Regulation?

A

An increase/decrease in blood glucose levels to within normal limits

41
Q

What hormones are involved in blood glucose regulation?

A

Insulin and glucagon are hormones involved in blood glucose regulation. Insulin is released to lower blood glucose levels and glucagon is released to increase blood glucose levels.

42
Q

Hyperglycaemia

A

Hyperglycaemia is a condition where there is an abnormally high level of glucose in the bloodstream, which can occur in individuals with type 1 diabetes who cannot absorb glucose due to insulin deficiency. Which can lead to damage to various organs and tissues in the body.

43
Q

Hypoglycaemia

A

Hypoglycaemia is a condition where blood glucose levels drop too low, causing symptoms such as shakiness, dizziness, confusion, and weakness. It can be caused by skipping meals, taking too much insulin, or excessive physical activity. Treatment typically involves consuming foods or drinks high in sugar or glucose, such as fruit juice or candy.

44
Q

What is osmoregulation?

A

It is the process by which the body regulates water balance and the concentration of solutes in the extracellular fluid.

45
Q

What happens when extracellular fluid has a high solute concentration?

A

Water will rush out of the cell via osmosis (crenate).

46
Q

What happens when extracellular fluid has a low solute concentration?

A

Water will rush into the cell (swell).

47
Q

What are the roles of water in the body?

A

It plays key roles in many fundamental processes of the body, including the production of urine, the removal of waste heat via the evaporation of sweat, the maintenance of blood volume within the circulatory system, and the protection of the brain and central nervous system.

48
Q

What is osmolality?

A

It is the concentration of solutes in a solution.

49
Q

What are osmoreceptors?

A

They are specialized cells in the hypothalamus that respond to changes in the osmolality of blood.

50
Q

What is the set point in osmoregulation?

A

It is the ideal concentration of solutes in the extracellular fluid.

51
Q

What are the primary effectors in osmoregulation?

A

Cells of the distal convoluted tubule and collecting duct in the nephrons of the kidneys, and the hypothalamus.

52
Q

What are baroreceptors?

A

They are specialized cells in the aortic arch, the carotid artery in the neck, and in the kidneys that respond to changes in blood volume and pressure.

53
Q

What is the endocrine system?

A

It is the collection of organs and glands in the body that are responsible for producing hormones.

54
Q

What is Type 1 diabetes?

A

Type 1 diabetes is an autoimmune disease where the body’s immune system attacks the beta cells in the pancreas, resulting in insulin deficiency and unregulated blood glucose levels.

55
Q

Symptoms of hyperglycaemia?

A

The short-term symptoms of hyperglycaemia include increased urination, excessive thirst, excessive hunger, lethargy, and weight loss.
The long-term consequences of hyperglycaemia include vision loss, heart disease and stroke, tingling or numbness in the feet and/or hands, prolonged wound healing, and kidney damage.

56
Q

Why is hypoglycaemia dangerous?

A

Hypoglycaemia is dangerous because it can cause weakness, dizziness, loss of consciousness, and even death, as cells do not have enough energy to function properly without glucose.

57
Q

How is type 1 diabetes managed?

A

Type 1 diabetes is managed through insulin replacement therapy, where patients measure their blood glucose levels and inject artificial insulin to regulate their blood glucose levels. They may use short-acting and long-acting insulin or an insulin pump.

58
Q

What is hyperthyroidism?

A

Hyperthyroidism is a condition where the thyroid gland produces too much T3 and T4, resulting in elevated hormone levels in the blood and reduced levels of TSH.

59
Q

What causes hyperthyroidism?

A

Hyperthyroidism can be caused by autoimmune diseases like Graves’ disease, which produces an autoantibody called TSI that binds to TSH receptors on the thyroid, stimulating it to release T3 and T4.

60
Q

What are the treatment options for hyperthyroidism?

A

Treatment options for hyperthyroidism include drugs like beta-blockers to reduce heart rate, antithyroid drugs to reduce hormone production, radioactive iodine to reduce the amount of hormone produced, and surgical removal of the thyroid gland.