Topic 9 - Drugs that affect the musculoskeletal system Flashcards

1
Q

Discuss why DMARDs such as methotrexate are use din the treatment of rheumatoid arthritis

A
  • Inhibition of neutrophil adhesion to endothelial cells which ↓ cell migration
  • T cell deactivation
  • ↑ intracellular adenosine and potentiate stimulation of α 2 receptors
  • Patient must be supplemented with folic acid with MTX use
  • Early diagnosis and treatment relieves pain, reduces inflammation and helps limit joint damage
  • Because irreversible damage takes place in the first 2 years of RA, early intervention is crucial
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2
Q

Discuss the role of bisphosphonates and pulsatile parathyroid hormone in the treatment of osteoporosis

A

Osteoblasts create bone and osteoclasts destroy bone. Bisphosphonates encourages osteoclasts to undergo apoptosis, therefore slowing the role of bone loss.

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